安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2014年
5期
906-908
,共3页
急性冠脉综合征%红细胞分布宽度%超敏C反应蛋白
急性冠脈綜閤徵%紅細胞分佈寬度%超敏C反應蛋白
급성관맥종합정%홍세포분포관도%초민C반응단백
acute coronary syndrome%red blood cell distribution width%high-sensitivity C-reactive protein
目的：了解冠心病患者中斑块稳定组与不稳定组之间红细胞分布宽度（ red blood cell distribution width ，RDW）是否有差异，是否能成为早期识别急性冠脉综合征（acute coronary syndromes，ACS）的一个潜在标记物；同时研究血清超敏C反应蛋白（hs-CRP），并探讨二者之间是否有联系。方法213例患者根据临床症状、相关标准及造影结果分成ACS组、SAP组及对照组，测定每位患者的RDW、hs-CRP及血脂指标。结果（1）ACS组RDW值显著高于SAP组及对照组，而SAP组与对照组之间无显著性差异；（2） ACS组hs-CRP显著高于SAP组及对照组，而SAP组与对照组之间无显著性差异；（3）多因素Longistic回归分析发现RDW水平与ACS之间存在独立的显著性相关关系；（4） RDW与血清hs-CRP呈显著性正相关。结论 ACS组患者RDW是明显升高的，提示RDW的升高可能参与斑块不稳定的进展过程，可能是反映斑块易损性的一个潜在标记物。
目的：瞭解冠心病患者中斑塊穩定組與不穩定組之間紅細胞分佈寬度（ red blood cell distribution width ，RDW）是否有差異，是否能成為早期識彆急性冠脈綜閤徵（acute coronary syndromes，ACS）的一箇潛在標記物；同時研究血清超敏C反應蛋白（hs-CRP），併探討二者之間是否有聯繫。方法213例患者根據臨床癥狀、相關標準及造影結果分成ACS組、SAP組及對照組，測定每位患者的RDW、hs-CRP及血脂指標。結果（1）ACS組RDW值顯著高于SAP組及對照組，而SAP組與對照組之間無顯著性差異；（2） ACS組hs-CRP顯著高于SAP組及對照組，而SAP組與對照組之間無顯著性差異；（3）多因素Longistic迴歸分析髮現RDW水平與ACS之間存在獨立的顯著性相關關繫；（4） RDW與血清hs-CRP呈顯著性正相關。結論 ACS組患者RDW是明顯升高的，提示RDW的升高可能參與斑塊不穩定的進展過程，可能是反映斑塊易損性的一箇潛在標記物。
목적：료해관심병환자중반괴은정조여불은정조지간홍세포분포관도（ red blood cell distribution width ，RDW）시부유차이，시부능성위조기식별급성관맥종합정（acute coronary syndromes，ACS）적일개잠재표기물；동시연구혈청초민C반응단백（hs-CRP），병탐토이자지간시부유련계。방법213례환자근거림상증상、상관표준급조영결과분성ACS조、SAP조급대조조，측정매위환자적RDW、hs-CRP급혈지지표。결과（1）ACS조RDW치현저고우SAP조급대조조，이SAP조여대조조지간무현저성차이；（2） ACS조hs-CRP현저고우SAP조급대조조，이SAP조여대조조지간무현저성차이；（3）다인소Longistic회귀분석발현RDW수평여ACS지간존재독립적현저성상관관계；（4） RDW여혈청hs-CRP정현저성정상관。결론 ACS조환자RDW시명현승고적，제시RDW적승고가능삼여반괴불은정적진전과정，가능시반영반괴역손성적일개잠재표기물。
Objective To explore whether RDW levels are different between the group of stable plaque and the group of unstable plaque in coronary heart disease and whether they can become a potential marker in early identification of ACS .The study also studied hs-CRP to explore whether they are associated with each other .Methods Two hundred and thirteen patients based on clinical symptoms ,rele-vant standards and results of angiography were assigned into ACS group ,SAP group and control group .RDW,hs-CRP and lipid parame-ters of each patient was measured .Results RDW in the ACS group was significantly higher than that in the SAP group and control group,while the SAP group and the control group had no significant difference .Hs-CRP in the ACS group was significantly higher than that in the SAP group and the control group ,while the SAP group and the control group had no significant difference .Multivariable lo-gistic regression analysis showed a significant independent relation between RDW and the presence of ACS .RDW and serum hs-CRP showed a significant positive correlation .Conclusions RDW of ACS patients are significantly elevated , which suggests that elevated RDW may be involved in the progression of plaque instability ,and may be a potential marker of plaque vulnerability .
