CAJ | 학술논문

目的了解广西地区新生儿葡萄糖-6-磷酸脱氢酶（G6PD ）缺乏症的发病情况，为患该病新生儿的防治提供参考依据。方法采用荧光法对本筛查中心的30556例新生儿进行G6 PD筛查检测，对可疑患儿召回并用G6PD/6PGD比值法进行确诊。结果所有被检测的新生儿中G6PD缺乏症的初筛阳性率是7．36％，其中男性为10．89％，女性为2．86％；对民族进行分组，汉族G6PD缺乏症的初筛阳性率是5．29％，壮族为9．54％，其他少数民族为5．42％。对可疑患儿召回确诊发现荧光法与G6PD/6PGD比值法的符合率为97％，重度G6PD缺陷者符合率达100％。结论荧光法准确性高、简便、快捷、费用低廉，广西壮族自治区作为G6PD缺乏症的高发区，应常规开展新生儿葡萄糖-6-磷酸脱氢酶缺乏症的筛查工作，使G6PD缺乏症患者能够及时采取预防性措施。
목적료해엄서지구신생인포도당-6-린산탈경매（G6PD ）결핍증적발병정황，위환해병신생인적방치제공삼고의거。방법채용형광법대본사사중심적30556례신생인진행G6 PD사사검측，대가의환인소회병용G6PD/6PGD비치법진행학진。결과소유피검측적신생인중G6PD결핍증적초사양성솔시7．36％，기중남성위10．89％，녀성위2．86％；대민족진행분조，한족G6PD결핍증적초사양성솔시5．29％，장족위9．54％，기타소수민족위5．42％。대가의환인소회학진발현형광법여G6PD/6PGD비치법적부합솔위97％，중도G6PD결함자부합솔체100％。결론형광법준학성고、간편、쾌첩、비용저렴，엄서장족자치구작위G6PD결핍증적고발구，응상규개전신생인포도당-6-린산탈경매결핍증적사사공작，사G6PD결핍증환자능구급시채취예방성조시。
Objective To investigate the incidence of neonatal glucose-6-phosphate dehydrogenase (G6PD) de-ficiency .Methods A total of 30 556 newborns were enrolled and detected for G6PD level by using fluorescence meth-od ,and G6PD/6PGD ratio test was performed for definite diagnosis in suspected cases .Results The screening inci-dence of G6PD deficiency was 7 .36% in all detected newborns ,and the rates in male and female were 10 .89% and 2 .86% .The screening positive rates in Han nationality ,Zhuang nationality and other minority nationalities were 5 . 29% ,9 .54% and 5 .42% respectively .The coincidence rate of fluorescence method and G 6PD/6PGD ration test was 97% and the coincidence rate in severe deficiency cases was 100% .Conclusion Screening of G6PD deficiency should be routinely performed in Guangxi to ensure the prevention strategies could be applied in time .