CAJ | 학술논문

目的分析金黄色葡萄球菌（SA）耐药情况和姜黄素及其新衍生物对其抑制的效果。方法采用法国梅里埃公司生产的全自动药敏鉴定仪鉴定，用滤纸保藏法保存菌株，姜黄素及其衍生物抑菌效果采用琼脂纸片扩散法进行测试。结果甲氧西林耐药金黄色葡萄球菌（M RS A ）呈多重耐药性，但未发现万古霉素耐药S A或万古霉素中介SA。甲氧西林敏感金黄色葡萄球菌（MSSA）除对青霉素、氨苄西林的耐药率为80％以上外，对其余抗菌药物均较敏感。姜黄素衍生物2号药物对SA菌株体外药敏有明显的抑菌环。结论临床治疗SA应根据药敏试验结果，合理使用抗药物。姜黄素衍生物的抑菌效果比姜黄素明显，其中2号衍生物效果最明显。
목적분석금황색포도구균（SA）내약정황화강황소급기신연생물대기억제적효과。방법채용법국매리애공사생산적전자동약민감정의감정，용려지보장법보존균주，강황소급기연생물억균효과채용경지지편확산법진행측시。결과갑양서림내약금황색포도구균（M RS A ）정다중내약성，단미발현만고매소내약S A혹만고매소중개SA。갑양서림민감금황색포도구균（MSSA）제대청매소、안변서림적내약솔위80％이상외，대기여항균약물균교민감。강황소연생물2호약물대SA균주체외약민유명현적억균배。결론림상치료SA응근거약민시험결과，합리사용항약물。강황소연생물적억균효과비강황소명현，기중2호연생물효과최명현。
Objective To analyze the drug resistance of Staphylococcus aureus (SA) and the inhibitory effects of curcumin and its derivatives on SA .Methods BioMerieux identification system were adopted for bacteria identifi-cation ,strains were preserved by filter paper method ,and the inhibitory effects of curcumin and its derivatives were detected by agar disk diffusion method .Results Methicillin resistant staphylococcus aureus were with multi-drug re-sistance ,but no vancomycin-resistant or vancomycin-intermediate SA was found .Resistance rates of methicillin sen-sitive staphylococcus aureus (MSSA) to penicillin and ampicillim were more than 80% ,but almost all MSSA were sensitive to other antimicrobial agents .No .2 curcumin derivative could inhibit SA proliferation obviously .Conclusion Antibiotics should be rationally used to therapy SA infection ,according to the results of drug sensitivity test .The inhibitory effects of curcumin derivatives ,especially No .2 derivative (curcumin FMO4) ,might be significantly obvi-ous than curcumin .