检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2013年
18期
2374-2375
,共2页
类风湿关节炎%抗突变型瓜氨酸波形蛋白抗体%抗瓜氨酸化纤维蛋白原抗体
類風濕關節炎%抗突變型瓜氨痠波形蛋白抗體%抗瓜氨痠化纖維蛋白原抗體
류풍습관절염%항돌변형과안산파형단백항체%항과안산화섬유단백원항체
rheumatoid arthritis%anti-mutant citrullinated vimentin%anti-citrullinated fibrinogen%anti-RA33
目的探讨抗突变型瓜氨酸波形蛋白（抗-MCV）抗体、抗瓜氨酸化纤维蛋白原抗体（ACF）、抗-RA33联合检测在类风湿关节炎（RA ）中的临床应用价值。方法对96例RA患者和50例其他自身免疫疾病患者及50名健康对照者采用酶联免疫吸附试验（ELISA）检测抗-MCV、抗-ACF、抗-RA33，观察各指标及3项联合检测对RA的诊断价值。结果单指标检测抗-MCV对RA的敏感性为84．37％（81/96），特异性为95．00％（95/100）；抗-ACF对RA的敏感性为64．58％（62/96），特异性为93．00％（93/100）；抗-RA33对RA的敏感性为13．54％（13/96），特异性为98．00％（98/100）。3项指标中任一指标阳性即作为阳性的敏感性最高（95．22％）；而3项指标均为阳性才视为阳性的敏感性略低于抗-ACF ，但特异性可达99．00％。结论抗-MCV、抗-ACF、抗-RA33是RA较为特异的指标，3项指标联合检测可以把阳性患者的误诊率降到最低，有助于对RA的早期诊断、治疗和病情预后估计。
目的探討抗突變型瓜氨痠波形蛋白（抗-MCV）抗體、抗瓜氨痠化纖維蛋白原抗體（ACF）、抗-RA33聯閤檢測在類風濕關節炎（RA ）中的臨床應用價值。方法對96例RA患者和50例其他自身免疫疾病患者及50名健康對照者採用酶聯免疫吸附試驗（ELISA）檢測抗-MCV、抗-ACF、抗-RA33，觀察各指標及3項聯閤檢測對RA的診斷價值。結果單指標檢測抗-MCV對RA的敏感性為84．37％（81/96），特異性為95．00％（95/100）；抗-ACF對RA的敏感性為64．58％（62/96），特異性為93．00％（93/100）；抗-RA33對RA的敏感性為13．54％（13/96），特異性為98．00％（98/100）。3項指標中任一指標暘性即作為暘性的敏感性最高（95．22％）；而3項指標均為暘性纔視為暘性的敏感性略低于抗-ACF ，但特異性可達99．00％。結論抗-MCV、抗-ACF、抗-RA33是RA較為特異的指標，3項指標聯閤檢測可以把暘性患者的誤診率降到最低，有助于對RA的早期診斷、治療和病情預後估計。
목적탐토항돌변형과안산파형단백（항-MCV）항체、항과안산화섬유단백원항체（ACF）、항-RA33연합검측재류풍습관절염（RA ）중적림상응용개치。방법대96례RA환자화50례기타자신면역질병환자급50명건강대조자채용매련면역흡부시험（ELISA）검측항-MCV、항-ACF、항-RA33，관찰각지표급3항연합검측대RA적진단개치。결과단지표검측항-MCV대RA적민감성위84．37％（81/96），특이성위95．00％（95/100）；항-ACF대RA적민감성위64．58％（62/96），특이성위93．00％（93/100）；항-RA33대RA적민감성위13．54％（13/96），특이성위98．00％（98/100）。3항지표중임일지표양성즉작위양성적민감성최고（95．22％）；이3항지표균위양성재시위양성적민감성략저우항-ACF ，단특이성가체99．00％。결론항-MCV、항-ACF、항-RA33시RA교위특이적지표，3항지표연합검측가이파양성환자적오진솔강도최저，유조우대RA적조기진단、치료화병정예후고계。
Objective To investigate the application value of combined detection of anti-mutant citrullinated vi-mentin (anti-MCV) ,anti-citrullinated fibrinogen (ACF) and anti-RA33 in rheumatoid arthritis (RA) .Methods 96 RA patients ,50 patients with other autoimmune diseases and 50 healthy controls were enrolled and detected for the three indicators by using enzyme-linked immunosorbent assay (ELISA) ,and the diagnosis value of single and com-bined detection was evaluated .Results For single detection ,the diagnostic sensitivity and specificity of anti-MCV for RA were 84 .37% (81/96) and 95 .00% (95/100) ,of ACF were 64 .58% (62/96) and 93 .00% (93/100) ,of anti-RA33 were 13 .54% (13/96) and 98 .00% (98/100) .Taking positive results of any of the three indicator as the crite-rion for positive results of combined detection ,the diagnostic sensitivity was the highest (95 .22% ) ,and taking posi-tive results of all of the three indicators as the criterion ,the sensitivity was lower than ACF ,but the specificity could reach 99 .00% .Conclusion anti-MCV ,ACF and anti-RA33 could be specific indicator of RA ,and combined detec-tion of the three indicators could minimize the misdiagnosis rate in patients with positive results and contribute to the early diagnosis ,treatment and prognostic estimation of RA .
