重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2013年
22期
2619-2620,2623
,共3页
C-反应蛋白%胱抑素C%痛风
C-反應蛋白%胱抑素C%痛風
C-반응단백%광억소C%통풍
C-reactive protein%cystatin C%gout
目的探讨C-反应蛋白（CRP）和胱抑素C（Cys C）联合检测对痛风患者早期肾功能损伤的诊断价值，为临床提供参考依据。方法选择四川省自贡市第一人民医院及重庆中医骨科医院住院和门诊痛风患者200例，根据肾小球滤过率（GFR）分为痛风伴肾功能早期损伤组（GFR 60～＜90 mL/min）和痛风不伴肾功能损伤组（GFR≥90 mL/min），每组各100例。用透射免疫比浊法在 OLYMPUS AU 400全自动生化分析仪上检测患者血清中 CRP和 Cys C水平。结果痛风伴肾功能早期损伤组患者血清CRP和Cys C水平均显著高于痛风不伴肾功能早期损伤组，二者比较差异有统计学意义（P＜0．05）。痛风伴肾功能早期损伤组患者血清CRP和Cys C阳性率分别为75％和81％，二者比较差异无统计学意义（P＞0．05）。而 CRP和 Cys C联合检测的阳性率为92％，显著高于单一指标的阳性检出率（P＜0．05）。结论 CRP和 Cys C联合检测可明显提高痛风患者早期肾功能损伤的阳性检出率。
目的探討C-反應蛋白（CRP）和胱抑素C（Cys C）聯閤檢測對痛風患者早期腎功能損傷的診斷價值，為臨床提供參攷依據。方法選擇四川省自貢市第一人民醫院及重慶中醫骨科醫院住院和門診痛風患者200例，根據腎小毬濾過率（GFR）分為痛風伴腎功能早期損傷組（GFR 60～＜90 mL/min）和痛風不伴腎功能損傷組（GFR≥90 mL/min），每組各100例。用透射免疫比濁法在 OLYMPUS AU 400全自動生化分析儀上檢測患者血清中 CRP和 Cys C水平。結果痛風伴腎功能早期損傷組患者血清CRP和Cys C水平均顯著高于痛風不伴腎功能早期損傷組，二者比較差異有統計學意義（P＜0．05）。痛風伴腎功能早期損傷組患者血清CRP和Cys C暘性率分彆為75％和81％，二者比較差異無統計學意義（P＞0．05）。而 CRP和 Cys C聯閤檢測的暘性率為92％，顯著高于單一指標的暘性檢齣率（P＜0．05）。結論 CRP和 Cys C聯閤檢測可明顯提高痛風患者早期腎功能損傷的暘性檢齣率。
목적탐토C-반응단백（CRP）화광억소C（Cys C）연합검측대통풍환자조기신공능손상적진단개치，위림상제공삼고의거。방법선택사천성자공시제일인민의원급중경중의골과의원주원화문진통풍환자200례，근거신소구려과솔（GFR）분위통풍반신공능조기손상조（GFR 60～＜90 mL/min）화통풍불반신공능손상조（GFR≥90 mL/min），매조각100례。용투사면역비탁법재 OLYMPUS AU 400전자동생화분석의상검측환자혈청중 CRP화 Cys C수평。결과통풍반신공능조기손상조환자혈청CRP화Cys C수평균현저고우통풍불반신공능조기손상조，이자비교차이유통계학의의（P＜0．05）。통풍반신공능조기손상조환자혈청CRP화Cys C양성솔분별위75％화81％，이자비교차이무통계학의의（P＞0．05）。이 CRP화 Cys C연합검측적양성솔위92％，현저고우단일지표적양성검출솔（P＜0．05）。결론 CRP화 Cys C연합검측가명현제고통풍환자조기신공능손상적양성검출솔。
Objective To evaluate the diagnostic value of combined detection of c-reactive protein(CRP)and cystatin C(Cys C) for early renal function impairment in gout patients,and to provide clinical reference.Methods Two hundred cases of gout patients were investigated and divided into experimental group and control group:experimental group patients(n=100)were with early renal function impairment and the control group(n=100)were without early renal impairment.The concentration of CRP and Cys C were detected with turbidimetric immunoassay method by OLYMPUS AU 400 automatic biochemistry analyzer.Results Serum CRP and Cys C concentrations of gout patients with early renal function impairment were significantly higher than those of gout patients without early renal function impairment(P<0.05).In the group of gout patients with early renal function impairment,the positive rate of serum CRP(75%)and Cys C(81%)had no significant difference(P>0.05).The positive rate of combination detection of CRP and Cys C was 92%,which was significantly higher than either CRP or Cys C(P<0.05).Conclusion The combination detec-tion of CRP and Cys C can improve diagnostis of early renal function impairment in gout patients.
