CAJ | 학술논문

现代有毒中药的概念是使用不当时,损伤人体的组织、器官,扰乱或破坏正常生理功能,产生病理变化甚至可能危及生命的中药.《中国药典》2010年版共收载毒性中药83种,其中大毒10种,有毒42种,小毒31种.目前我国在有毒中药的药效组分学研究、毒代动力学研究、代谢组学研究等方面都取得了一定进展,但也存在纳入中药安全性评价研究的种类少、研究方法较局限、管理尚不规范等问题.借鉴国外安全性评价方法、制定严格规范的质量标准等都是保障有毒中药合理应用的有效方法.
현대유독중약적개념시사용불당시,손상인체적조직、기관,우란혹파배정상생리공능,산생병리변화심지가능위급생명적중약.《중국약전》2010년판공수재독성중약83충,기중대독10충,유독42충,소독31충.목전아국재유독중약적약효조분학연구、독대동역학연구、대사조학연구등방면도취득료일정진전,단야존재납입중약안전성평개연구적충류소、연구방법교국한、관리상불규범등문제.차감국외안전성평개방법、제정엄격규범적질량표준등도시보장유독중약합리응용적유효방법.
The toxic traditional Chinese medicine (TCM) is the drugs that may damage the body's tissues and organs,disrupt or destroy the normal physiological function,lead to pathologic changes,and even threaten life when the drugs are improperly used.Totally 83 kinds of toxic TCM,including 10 kinds of extremely toxic,42 kinds of toxic,and 31 kinds of slightly toxic TCM as described in the Chinese Pharmacopoeia (2010).Currently,progresses have been made in the studies on bioactive components,toxicokinetics,and metabonomics of the toxic TCM in our country.But some problems still exist,such as relatively small species members of TCM were entered in the safety evaluation research,limited study methods,and the non-standard management.The effective ways to promote rational use of toxic TCM include some measures such as learning the safety evaluation methods in other counties and formulating the strict quality standards.