CAJ | 학술논문

目的探讨胃肠道间变性大细胞淋巴瘤(ALCL)的临床病理学特征、免疫组织化学表型特点.方法对3例确诊为ALCL患者的临床表现、组织形态及免疫表型进行分析,并复习相关文献.结果 ALCL临床无特征性改变,病理学组织形态呈多形性,包括不等量的怪异核、马蹄铁或肾形核,其中1例以肉瘤样特征为主.免疫组织化学均表达LCA、CD3、CD4、CD5、CD45Ro、CD30; ALK(2／3)阳性表达;不表达B细胞相关抗原、CD15及肌源性、神经源性、上皮源性抗原.结论 ALCL是罕见的胃肠道淋巴造血系统肿瘤,无明确临床特征,恶性度高,常被误诊为癌或肉瘤,需要活组织检查及病理确诊.
목적 탐토위장도간변성대세포림파류(ALCL)적림상병이학특정、면역조직화학표형특점.방법 대3례학진위ALCL환자적림상표현、조직형태급면역표형진행분석,병복습상관문헌.결과 ALCL림상무특정성개변,병이학조직형태정다형성,포괄불등량적괴이핵、마제철혹신형핵,기중1례이육류양특정위주.면역조직화학균표체LCA、CD3、CD4、CD5、CD45Ro、CD30; ALK(2／3)양성표체;불표체B세포상관항원、CD15급기원성、신경원성、상피원성항원.결론 ALCL시한견적위장도림파조혈계통종류,무명학림상특정,악성도고,상피오진위암혹육류,수요활조직검사급병리학진.
Objective To explore the clinicopathological features,immunohistochemical characteristics of gastrointestinal anaplastic large cell lymphoma (ALCL).Methods Clinical manifestations,histology and immunophenotype of three cases diagnosed with gastrointestinal ALCL were analyzed with the review of related literatures.Results The clinical manifestations of gastrointestinal ALCL were of no characteristical changes.The pathological features were pleomorphic in which some bizarre,horseshoed or kidney-shaped nuclei were seen.The characteristic of one of the three cases was shown as sarcomatoid.All cases expressed LCA,CD3,CD4,CDs,CD45Ro,CD30,two out of three cases expressed ALK protein,otherwise they were negative for B cell related antigens,CD15 and muscle,nerve,epithelium originated antigens.Conclusions ALCL of the gastrointestinal tract is extremely rare as one of the lymphatic hematopoietic system tumors.No definite clinical characteristic is seen in the gastrointestinal ALCL with high grade malignancy.It is easily misdiagnosed as carcinomas or other sarcomas.It is necessary to use biopsy to make a pathological diagnosis.