CAJ | 학술논문

目的探讨噻托溴铵粉吸入剂对稳定期中重度COPD患者的治疗效果.方法选取我院2010年2月至2012年3月收治的90例稳定期中重度COPD患者90例,随机分为实验组和对照组各45例.两组患者均接受常规治疗,实验组在常规治疗的基础上采用噻托溴铵粉吸入剂.记录两组患者吸入药物前、吸入药物6周和12周的肺功能指标,包括1秒用力呼气量(FEVl)、用力肺活量(FVC)、深吸气量(IC),并记录两组患者的6分钟步行距离(6MWD)和不良反应发生率.结果治疗后6周和12周,实验组FEV1、FVC、IC、6MWD等指标均优于对照组,差异有显著性(P＜0.05).对照组不良反应发生率为4.4％,实验组为8.9％,差异有统计学意义(P＜0.05).结论噻托溴铵粉吸入剂对稳定期中重度COPD患者疗效显著,安全性高,值得临床推广使用.
목적 탐토새탁추안분흡입제대은정기중중도COPD환자적치료효과.방법 선취아원2010년2월지2012년3월수치적90례은정기중중도COPD환자90례,수궤분위실험조화대조조각45례.량조환자균접수상규치료,실험조재상규치료적기출상채용새탁추안분흡입제.기록량조환자흡입약물전、흡입약물6주화12주적폐공능지표,포괄1초용력호기량(FEVl)、용력폐활량(FVC)、심흡기량(IC),병기록량조환자적6분종보행거리(6MWD)화불량반응발생솔.결과 치료후6주화12주,실험조FEV1、FVC、IC、6MWD등지표균우우대조조,차이유현저성(P＜0.05).대조조불량반응발생솔위4.4％,실험조위8.9％,차이유통계학의의(P＜0.05).결론 새탁추안분흡입제대은정기중중도COPD환자료효현저,안전성고,치득림상추엄사용.
Objective To explore the effect of tiotropium bromide powder inhalation in treatment of stable moderate to severe chronic obstructive pulmonary disease (COPD).Methods 90 cases of stable moderate to severe COPD admitted into our hospital from February 2010 to March 2012 were selected as objects.They were randomly divided into control group and experiment group,45 cases for each group.Routine nursing was given to two groups and tiotropium bromide powder inhalation was given to the experiment group.The pulmonary function indicatrix before taking medicine,6 and 12 weeks after taking medicine of them was recorded,including FEV1,FVC,IC,6MWD and adverse effects rate.Results After 6 and 12 weeks treatment,the FEV1,FVC,IC and 6MWD in the experiment group were superior than those of control group,the difference was statistically significant (P ＜ 0.05).The adverse effects rate was 8.9％ in the control group and 4.4％ in experiment group,thc difference was statistically significant (P ＜ 0.05).Conclusions We think that tiotropium bromide powder inhalation has great effect on stable moderate to severe COPD.It is safe and worth to be widely promoted in clinic.