CAJ | 학술논문

背景阿片类药物是临床上治疗慢性癌痛和非癌性疼痛最常用的药物之一.其副作用之一,阿片类药物诱导的痛觉过敏(opioid-induced hyperalgesia,OIH)正越来越受到研究者们的关注,然而其具体的发生机制和治疗方法尚不明确.目的探讨OIH在动物和人体中的可能表现形式和发生机制,寻找有效的预防和治疗OIH的方法,提高对慢性疼痛患者治疗的临床疗效. 内容已有大量动物和临床实验报道了OIH的可能表现形式并证实了OIH的存在.OIH的发生机制主要包括腺苷酸环化酶的活性增强、离子通道瞬时受体电位香草醛亚家族1(transient receptor potential vanilloid 1,TRPV1)基因转录的增加、内源性感觉神经肽的增多等.对于预防和治疗OIH学者们提出了多种方法,其中有些方法的疗效已在临床研究中得到证实. 趋向我们还需进一步研究OIH的机制,探索更加有效和持久的治疗和护理方法,更好地为患者造福.
배경 아편류약물시림상상치료만성암통화비암성동통최상용적약물지일.기부작용지일,아편류약물유도적통각과민(opioid-induced hyperalgesia,OIH)정월래월수도연구자문적관주,연이기구체적발생궤제화치료방법상불명학.목적 탐토OIH재동물화인체중적가능표현형식화발생궤제,심조유효적예방화치료OIH적방법,제고대만성동통환자치료적림상료효. 내용 이유대량동물화림상실험보도료OIH적가능표현형식병증실료OIH적존재.OIH적발생궤제주요포괄선감산배화매적활성증강、리자통도순시수체전위향초철아가족1(transient receptor potential vanilloid 1,TRPV1)기인전록적증가、내원성감각신경태적증다등.대우예방화치료OIH학자문제출료다충방법,기중유사방법적료효이재림상연구중득도증실. 추향 아문환수진일보연구OIH적궤제,탐색경가유효화지구적치료화호리방법,경호지위환자조복.
Background Opioid is one of the most common drugs being used in cancer pain or chronic non-cancer pain.Opioid-induced hyperalgesia (OIH),one of opioid side effects,is increasing nowadays.Objective Discussion on the possible patterns of manifestation and mechanism of OIH on animals or human.To find effective ways to preventing and treating OIH.To improve the outcomes of chromic pain management.Content A large amount of animal or clinical researches had demonstrated the possible manifestation of OIH.The mechanisms of OIH are related to increasing activity of adenylate cyclase,up-regulation of the transient receptor potential vanilloid 1 (TRPV1) channel's expression and increasing number of endogenous neuropeptides.Many researchers put forward different ways to preventing and treating OIH.Trend It is needed for further study of the mechanisms and treatments of OIH.