交通医学
交通醫學
교통의학
MEDICAL JOURNAL OF COMMUNICATIONS
2013年
5期
433-434,438
,共3页
高刚%王军%马莉%钱茂华
高剛%王軍%馬莉%錢茂華
고강%왕군%마리%전무화
慢性咳嗽%咽喉反流疾病%奥美拉唑%电子鼻咽喉镜检查%反流检查计分量表%反流症状指数量表
慢性咳嗽%嚥喉反流疾病%奧美拉唑%電子鼻嚥喉鏡檢查%反流檢查計分量錶%反流癥狀指數量錶
만성해수%인후반류질병%오미랍서%전자비인후경검사%반류검사계분량표%반류증상지수량표
proton pump inhibitors(PPIs)%chronic cough%laryngopharyngeal reflux disease(LPRD)%omeprazole
目的：评价质子泵抑制剂奥美拉唑在慢性咳嗽治疗中的应用价值。方法：选择耳鼻咽喉头颈外科门诊就诊的慢性咳嗽患者63例，除外其他内科疾病及耳鼻咽喉科其他疾病，依据临床症状分为2组：有反酸症状组39例及无反酸症状组24例。对2组患者均予以奥美拉唑肠溶片口服，观察治疗前后的咳嗽VAS评分、反流检查计分量表（The reflux finding score, RFS）和反流症状指数量表（The reflux symptom index, RSI）评分，并对结果进行比较分析。结果：反酸症状组39例中35例（89.74％）经抑酸治疗咳嗽消失或不同程度缓解。无反酸症状组21例（退出3例）中9例（42.86%）经抑酸治疗咳嗽消失。反酸症状组治疗后2周、1个月各项评分与治疗前比较，差异均有统计学意义（P<0.05）；无反酸症状组仅RSI评分项差异有统计学意义（P<0.05）。结论：慢性咳嗽有部分可归因于咽喉反流疾病，抑酸治疗有明显效果，而无反酸症状者抑酸治疗亦有一定价值。
目的：評價質子泵抑製劑奧美拉唑在慢性咳嗽治療中的應用價值。方法：選擇耳鼻嚥喉頭頸外科門診就診的慢性咳嗽患者63例，除外其他內科疾病及耳鼻嚥喉科其他疾病，依據臨床癥狀分為2組：有反痠癥狀組39例及無反痠癥狀組24例。對2組患者均予以奧美拉唑腸溶片口服，觀察治療前後的咳嗽VAS評分、反流檢查計分量錶（The reflux finding score, RFS）和反流癥狀指數量錶（The reflux symptom index, RSI）評分，併對結果進行比較分析。結果：反痠癥狀組39例中35例（89.74％）經抑痠治療咳嗽消失或不同程度緩解。無反痠癥狀組21例（退齣3例）中9例（42.86%）經抑痠治療咳嗽消失。反痠癥狀組治療後2週、1箇月各項評分與治療前比較，差異均有統計學意義（P<0.05）；無反痠癥狀組僅RSI評分項差異有統計學意義（P<0.05）。結論：慢性咳嗽有部分可歸因于嚥喉反流疾病，抑痠治療有明顯效果，而無反痠癥狀者抑痠治療亦有一定價值。
목적：평개질자빙억제제오미랍서재만성해수치료중적응용개치。방법：선택이비인후두경외과문진취진적만성해수환자63례，제외기타내과질병급이비인후과기타질병，의거림상증상분위2조：유반산증상조39례급무반산증상조24례。대2조환자균여이오미랍서장용편구복，관찰치료전후적해수VAS평분、반류검사계분량표（The reflux finding score, RFS）화반류증상지수량표（The reflux symptom index, RSI）평분，병대결과진행비교분석。결과：반산증상조39례중35례（89.74％）경억산치료해수소실혹불동정도완해。무반산증상조21례（퇴출3례）중9례（42.86%）경억산치료해수소실。반산증상조치료후2주、1개월각항평분여치료전비교，차이균유통계학의의（P<0.05）；무반산증상조부RSI평분항차이유통계학의의（P<0.05）。결론：만성해수유부분가귀인우인후반류질병，억산치료유명현효과，이무반산증상자억산치료역유일정개치。
Objective: To evaluate the value of proton pump inhibitors (PPIs) in the treatment of chronic cough. Methods: 63 outpatients with chronic cough were chosen in Otolaryngology Head and Neck Surgery of our hospital from June 2010 to August 2012, who suffered from no other medical diseases or no other diseases of Otolaryngology and who, based on clinical symptoms, were divided into two groups:the group with symptoms of acid reflux (Group A) and the group with no symptoms of acid reflux (Group B). Both groups of patients were administered orally enteric-coated tablets of omeprazole, and then VAS score and reflux checking account subscale (The reflux finding score, RFS) and reflux symptoms index scale (The reflux symptom index, RSI) score were used to evaluate the therapeutic effects. Results:The cough disap-peared or relieved after PPIs therapy in 89.74%(35/39) patients of Group A. 3 patients in 24 cases in Group B exited in the follow-up. The cough disappeared or relieved after PPIs therapy in 42.86%(9/21) patients in Group B. Compared with those before treatment, the differences of the scores of each period of time after PPIs therapy in the patients of Group A were sta-tistically significant (P<0.05). Conclusion: Except the patients with chronic cough caused by medical diseases, chronic cough is partly attributed to the LPRD, and PPIs therapy has a marked effect. For the patients with no symptoms of acid re-flux therapy of chronic cough also has a certain value.
