CAJ | 학술논문

随着糖尿病患者的逐年增多，糖尿病女性的不孕问题也越来越突出。研究发现，机体内长期未控制的高血糖环境可通过影响卵泡细胞内线粒体功能、卵巢内Ang域等刺激因子水平以及血中多种内分泌激素（如雌二醇、睾酮、孕激素和血胰岛素等）的浓度来影响卵巢内卵母细胞的成熟以及排出，损伤卵巢功能进而影响妊娠。控制血糖水平以及改善胰岛素抵抗等可能对改善糖尿病女性的卵巢功能有一定作用。
수착당뇨병환자적축년증다，당뇨병녀성적불잉문제야월래월돌출。연구발현，궤체내장기미공제적고혈당배경가통과영향란포세포내선립체공능、란소내Ang역등자격인자수평이급혈중다충내분비격소（여자이순、고동、잉격소화혈이도소등）적농도래영향란소내란모세포적성숙이급배출，손상란소공능진이영향임신。공제혈당수평이급개선이도소저항등가능대개선당뇨병녀성적란소공능유일정작용。
The number of patients with diabetes increased year by year. The infertility in those diabetic women is of important problem. It was found that the environment of long-term uncontrolled hyperglycemia could affect ovarian function and pregnancy by its effect on oocyte maturation and ovulation. The mechanism could be complicated, including the disturbed mitochondrial function of follicle cells, those ovarian stimulating factors such as Ang II, and the changed concentration of many hormones in blood (such as E2, T, P, insulin). It is benefit to improve ovarian function for those women with diabetes to control their blood glucose levels and to improve insulin resistance.