CAJ | 학술논문

多囊卵巢综合征（PCOS）是一种育龄妇女常见的内分泌疾病，多数患者因育龄期不孕就诊。PCOS患者经过药物治疗纠正内分泌紊乱、恢复正常排卵后仍有低妊娠率和高流产率，这可能是由于长期的激素失调使子宫内膜容受性下降所致。国内外大量文献研究表明，透明质酸（HA）、黏蛋白（MUC1）、钙黏附蛋白（E-cadherin）、G蛋白耦联雌激素受体（GPER）等分子均在子宫内膜周期性表达，并在不孕患者子宫内膜异常表达，提示HA、MUC1、E-cadherin、GPER与子宫内膜容受性有关。综述这4类蛋白分子与PCOS患者子宫内膜容受性关系的研究进展。
다낭란소종합정（PCOS）시일충육령부녀상견적내분비질병，다수환자인육령기불잉취진。PCOS환자경과약물치료규정내분비문란、회복정상배란후잉유저임신솔화고유산솔，저가능시유우장기적격소실조사자궁내막용수성하강소치。국내외대량문헌연구표명，투명질산（HA）、점단백（MUC1）、개점부단백（E-cadherin）、G단백우련자격소수체（GPER）등분자균재자궁내막주기성표체，병재불잉환자자궁내막이상표체，제시HA、MUC1、E-cadherin、GPER여자궁내막용수성유관。종술저4류단백분자여PCOS환자자궁내막용수성관계적연구진전。
Polycystic ovarian syndrome (PCOS) is a common endocrine disease in women of childbearing age. Most of patients with PCOS visit doctors because of their infertility. Patients with PCOS still have the high rate of abortion and low rate of pregnancy, although their ovulation and endocrine have been adjusted by drug treatment, which is mostly due to the lowered endometrial receptivity induced by long term of hormonal imbalance. It was shown that HA, MUC1, E-cadherin and GPER cyclically expressed in endometrium, and that expressions of these proteins were abnormal in endometrium of patients with infertility. It suggested that HA, MUC1, E-cadherin and GPER were bound up with endometrial receptivity. In this paper, roles of these factors were reviewed in the lowered endometrial receptivity of PCOS.