CAJ | 학술논문

目的：研制黄芩苷缓释微囊并进行稳定性考察。方法运用复凝聚法以明胶和阿拉伯胶为囊材，黄芩苷为囊心物，吐温-80为润湿剂制备微囊。以包封率作为质量判定指标，采用单因素考察和正交试验优化处方工艺。结果得出最优处方是明胶和阿拉伯胶浓度皆为1.33%g/mL，反应温度50℃，pH值3.90，材药比为5：1。按该处方制得的微囊囊型圆整光滑，载药量较高，并具有一定的缓释效果。结论复凝聚法可成功制备出包封率较高的黄芩苷微囊，且产品稳定性良好。该法可操作性强，重复性好，有一定的实用价值。
목적：연제황금감완석미낭병진행은정성고찰。방법운용복응취법이명효화아랍백효위낭재，황금감위낭심물，토온-80위윤습제제비미낭。이포봉솔작위질량판정지표，채용단인소고찰화정교시험우화처방공예。결과득출최우처방시명효화아랍백효농도개위1.33%g/mL，반응온도50℃，pH치3.90，재약비위5：1。안해처방제득적미낭낭형원정광활，재약량교고，병구유일정적완석효과。결론복응취법가성공제비출포봉솔교고적황금감미낭，차산품은정성량호。해법가조작성강，중복성호，유일정적실용개치。
Objective: To developing sustained release microcapsules of baicalin and investigate its stability. Methods:The baicalin microcapsules were prepared by using gelatin and arabic gum as wall materials, baicalin as core and Tween-80 as wetting agent. Encapsulation efficiency as the quality indicator, the formulation and technology was optimized by single phoneme and orthogonal experiment. Results: The optimum parameters were that the concentrations of both gelatin and arabic gum were 1.33%g/mL, the temperature was 50℃, pH was 3.90, and the ratio of wall materials to core was 5:1. The prepared baicalin microcapsules were spherical with smooth surface, high encapsulation efficiency and time-release effect. Conclusion: The baicalin microcapsule could be prepared by complex coacervation method with good stability successfully. This method was easily operated with good repeatability and strong maneuverability.