CAJ | 학술논문

以ZrCl4为催化剂，芳胺和醛为原料，采用“一锅法”合成了喹啉衍生物；考察了空气、催化剂用量、原料比例以及芳胺的取代基等因素对反应收率的影响；利用高分辨质谱和核磁共振谱（1 H NMR、13 C NMR）表征了产物的分子结构。结果表明，以苯胺和正丁醛为原料时，3-乙基-2-丙基喹啉的收率可达65％，同时生成27％的N-丁基苯胺；工艺经改进后，反应条件温和、操作简便、催化剂用量少、产物收率高。
이ZrCl4위최화제，방알화철위원료，채용“일과법”합성료규람연생물；고찰료공기、최화제용량、원료비례이급방알적취대기등인소대반응수솔적영향；이용고분변질보화핵자공진보（1 H NMR、13 C NMR）표정료산물적분자결구。결과표명，이분알화정정철위원료시，3-을기-2-병기규람적수솔가체65％，동시생성27％적N-정기분알；공예경개진후，반응조건온화、조작간편、최화제용량소、산물수솔고。
Quinoline derivatives were synthesized via one-pot reaction of aromatic amine and al-dehyde in the presence of ZrCl4 catalyst .The effects of atmosphere ,catalyst dosage ,raw mate-rial ratios ,and substituent of aniline on the yield were investigated .The molecular structure of as-synthesized products was analyzed by high resolution mass spectrometry and nuclear mag-netic resonance spectroscopy (1 H NMR and 13C NMR) .Results show that the catalyzed reac-tion of aniline and n-butylaldehyde affords 3-ethyl-2-propylquinoline in a yield of 65% and by-product N-butylaniline in a yield of 27% .Thanks to the modification of reaction process ,the established new method for synthesizing quinoline derivatives has advantages of mild reaction condition ,convenient operation ,high catalytic efficiency ,and high yield .