CAJ | 학술논문

目的：探讨复方甘草酸苷联合丹皮酚软膏治疗变应性接触性皮炎（ ACD）的临床。方法：96例ACD患者被随机分为对照组和治疗组，每组各为48例。对照组口服复方甘草酸苷片3次/d，2片/次。治疗组在对照组基础上外用丹皮酚软膏，2次/d。治疗后观察和比较两组临床疗效、症状积分和免疫因子水平变化及不良反应情况。结果：治疗组治疗后痊愈率和总有效率分别达到66.67％和85.42％，显著高于对照组痊愈率和总有效率（ P＜0.05）；治疗组治疗1、2和3周后症状积分分别为（5.23±1.1）分、（3.07±1.08）分和（1.32±0.82）分，均显著低于治疗前和对照组治疗后水平（P＜0.05）；治疗后sIL-2R为（2.11±0.76）ng/mL，显著低于对照组（P＜0.05），而IL-2和IFN-γ水平为（28.14±2.37）pg/mL和（28.04±11.06）pg/mL，显著高于对照组（P＜0.05）；两组不良反应率无统计学意义（P＜0.05）。结论：口服复方甘草酸苷联合外用丹皮酚软膏，能显著改善ACD患者症状评分，降低炎性因子水平，不良反应少，疗效显著优于单用复方甘草酸苷。
목적：탐토복방감초산감연합단피분연고치료변응성접촉성피염（ ACD）적림상。방법：96례ACD환자피수궤분위대조조화치료조，매조각위48례。대조조구복복방감초산감편3차/d，2편/차。치료조재대조조기출상외용단피분연고，2차/d。치료후관찰화비교량조림상료효、증상적분화면역인자수평변화급불량반응정황。결과：치료조치료후전유솔화총유효솔분별체도66.67％화85.42％，현저고우대조조전유솔화총유효솔（ P＜0.05）；치료조치료1、2화3주후증상적분분별위（5.23±1.1）분、（3.07±1.08）분화（1.32±0.82）분，균현저저우치료전화대조조치료후수평（P＜0.05）；치료후sIL-2R위（2.11±0.76）ng/mL，현저저우대조조（P＜0.05），이IL-2화IFN-γ수평위（28.14±2.37）pg/mL화（28.04±11.06）pg/mL，현저고우대조조（P＜0.05）；량조불량반응솔무통계학의의（P＜0.05）。결론：구복복방감초산감연합외용단피분연고，능현저개선ACD환자증상평분，강저염성인자수평，불량반응소，료효현저우우단용복방감초산감。
Objective: To investigate the clinical observation of glycyrrhizic acid compound combined with Paeonol on allergic contact dermatitis (ACD).Methods:Ninety six patients with ACD were randomly divided into the control group (n=48) and the observation group (n=48).The control group applied oral compound glycyrrhizin glucoside tablets three times a day , two tablets each time.The observation group applied Paeonol ointment topically two times a day except form the treatment of the control group .The clinical curative effect, symptom integral and immune factor level change as well as the adverse reactions between two groups after treatment were ob -served and compared .Results:The curative rate and total effective rate after treatment in the observation groups were 66.67%and 85. 42% respectively, which were both significantly higher than those of the control groups (P<0.05).The symptoms integral scores after 1, 2, and 3 weeks of treatment in the observation group were (5.23 ±1.1) points, (3.07 ±1.08) points and (1.32 ±0.82) points re-spectively, which were all significantly lower than those before treatment and of the control group after treatment (P<0.05).The level of sIL-2R in the observation group after treatment was (2.11 ±0.76) ng/mL, which was significantly lower than that of the control group (P<0.05) while the level of the IL -2 and IFN-γwere (28.14 ±2.37) pg/mL and (28.04 ±11.06) pg/mL, which were both significantly higher than those of the control groups (P<0.05).The adverse reaction rate between the two groups had no significant difference (P<0.05).Conclusion:The compound glycyrrhizin glucoside combined with the Paeonol ointment could significantly im -prove the symptom scores in patients with ACD , reduce the levels of inflammatory cytokines with few adverse reactions .The curative effect was significantly better than single application of the compound glycyrrhizin glucoside .