浙江中医药大学学报
浙江中醫藥大學學報
절강중의약대학학보
JOURNAL OF ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
2013年
11期
1322-1323
,共2页
糖尿病%妊娠%Hcy%VitB12%FA
糖尿病%妊娠%Hcy%VitB12%FA
당뇨병%임신%Hcy%VitB12%FA
diabetes%pregnant%Hcy%VitB12%FA
[目的]探讨妊娠期糖尿病(gestational diabetes mel itus，GDM)患者血清叶酸(folic acid，FA)、维生素(vitamin，Vit)B12和同型半胱氨酸(homocys-teine，Hcy)水平及其与GDM的关系。[方法]选择2011年6月至2012年12月我院经口服葡萄糖耐量试验（oral glucose tolerance test，0GTT）确诊的GDM患者40例及同期健康孕妇40例，采用循环酶法检测Hcy浓度；采用化学发光免疫法检测FA及VitB12水平。[结果] GDM患者血清Hcy、VitB12、FA与正常妊娠组比较，Hcy水平显著升高（P<0.01），FA和VitB12显著降低（P<0.01）。GDM患者血清Hcy水平与VitBl2、FA水平呈负相关关系。[结论] GDM孕晚期患者出现高Hcy血症，缺乏FA及VitB12，妊高症患者应加强VitB12和FA的摄入及定期监测，从而降低Hcy水平，减轻其对GDM孕妇大血管和微血管的损害以及对胎儿的不良影响。
[目的]探討妊娠期糖尿病(gestational diabetes mel itus，GDM)患者血清葉痠(folic acid，FA)、維生素(vitamin，Vit)B12和同型半胱氨痠(homocys-teine，Hcy)水平及其與GDM的關繫。[方法]選擇2011年6月至2012年12月我院經口服葡萄糖耐量試驗（oral glucose tolerance test，0GTT）確診的GDM患者40例及同期健康孕婦40例，採用循環酶法檢測Hcy濃度；採用化學髮光免疫法檢測FA及VitB12水平。[結果] GDM患者血清Hcy、VitB12、FA與正常妊娠組比較，Hcy水平顯著升高（P<0.01），FA和VitB12顯著降低（P<0.01）。GDM患者血清Hcy水平與VitBl2、FA水平呈負相關關繫。[結論] GDM孕晚期患者齣現高Hcy血癥，缺乏FA及VitB12，妊高癥患者應加彊VitB12和FA的攝入及定期鑑測，從而降低Hcy水平，減輕其對GDM孕婦大血管和微血管的損害以及對胎兒的不良影響。
[목적]탐토임신기당뇨병(gestational diabetes mel itus，GDM)환자혈청협산(folic acid，FA)、유생소(vitamin，Vit)B12화동형반광안산(homocys-teine，Hcy)수평급기여GDM적관계。[방법]선택2011년6월지2012년12월아원경구복포도당내량시험（oral glucose tolerance test，0GTT）학진적GDM환자40례급동기건강잉부40례，채용순배매법검측Hcy농도；채용화학발광면역법검측FA급VitB12수평。[결과] GDM환자혈청Hcy、VitB12、FA여정상임신조비교，Hcy수평현저승고（P<0.01），FA화VitB12현저강저（P<0.01）。GDM환자혈청Hcy수평여VitBl2、FA수평정부상관관계。[결론] GDM잉만기환자출현고Hcy혈증，결핍FA급VitB12，임고증환자응가강VitB12화FA적섭입급정기감측，종이강저Hcy수평，감경기대GDM잉부대혈관화미혈관적손해이급대태인적불량영향。
[Objective] To explore the levels of folic acid(FA), vitamin(Vit) Bl2 and homocysteine(Hcy) of gestational diabetes mel itus(GDM) patients and the relation among them. [Method] Select 40 GDM cases from our hospital diagnosed with oral glucose tolerance test(0GTT) and 40 healthy pregnant women in the same period, take circulation enzymic method to test Hcy concentration, and take chemiluminescence to measure FA and VitBl2. [Result] GDM patients’Hcy level is in negative relation with VitBl2 and FA levels. Comparing GDM patients’serum Hcy,VitBl2 and FA with normal pregnant group,Hcy level is raised much(P<0.01), FA and VitBl2 are reduced markedly(P<0.01). In later period of GDM pregnancy, they have high Hcy, lack of FA and Vit-Bl2; the pregnancy hypertension shal strengthen the intake of VitBl2 and FA, as wel as have periodical supervision, to reduce Hcy level and decrease the side effects on fetus and injury to pregnant women’s great vessels and micro-vessels.
