CAJ | 학술논문

目的：利用Meta分析的方法，综合评价LRP5基因A1330V位点多态性与东亚人群骨密度（ BMD）的相关性。方法计算机检索Pubmed、Embase、中国生物医学文献数据库和万方数据库数据库等，并手工检索相关杂志，收集有关东亚人群LRP5基因A1330V位点多态性的基因型频率与BMD相关性的研究。检索时间截止至2012年11月。在评价纳入研究质量，提取有效数据后，采用Stata 12.0软件进行Meta分析。结果共11项研究符合既定的纳入和排除标准，合计5906名研究对象。Meta分析结果显示：AA 基因型较 AV/VV 基因型腰椎 BMD 高，且差异有统计学意义[ SMD ＝0.107，95％CI （0.044，0.171）]。在股骨颈BMD方面，AA基因型高于AV/VV基因型[SMD＝0.190，95％CI （0.034，0.346）]。 AA基因型的桡骨、全身BMD也高于AV/VV基因型。但是， AA基因型群体的转子间BMD 与AV/VV基因型的差异无统计学意义[ SMD ＝0.090，95％CI （-0.029，1.143）]。除腰椎、转子间BMD以外，AA基因型群体的股骨颈、桡骨以及全身BMD高于VV基因型，但此基因型间比较的纳入研究数量过少，证据尚不充分。结论本Meta分析结果提示，东亚人群中LRP5基因A1330V位点的突变可能与骨密度的变化具有相关性，尤其AA基因型人群在股骨颈、腰椎部位有比AV/VV或VV基因型人群更高的骨密度值。但目前的结论尚需进一步大样本、高质量的研究去验证。
목적：이용Meta분석적방법，종합평개LRP5기인A1330V위점다태성여동아인군골밀도（ BMD）적상관성。방법계산궤검색Pubmed、Embase、중국생물의학문헌수거고화만방수거고수거고등，병수공검색상관잡지，수집유관동아인군LRP5기인A1330V위점다태성적기인형빈솔여BMD상관성적연구。검색시간절지지2012년11월。재평개납입연구질량，제취유효수거후，채용Stata 12.0연건진행Meta분석。결과공11항연구부합기정적납입화배제표준，합계5906명연구대상。Meta분석결과현시：AA 기인형교 AV/VV 기인형요추 BMD 고，차차이유통계학의의[ SMD ＝0.107，95％CI （0.044，0.171）]。재고골경BMD방면，AA기인형고우AV/VV기인형[SMD＝0.190，95％CI （0.034，0.346）]。 AA기인형적뇨골、전신BMD야고우AV/VV기인형。단시， AA기인형군체적전자간BMD 여AV/VV기인형적차이무통계학의의[ SMD ＝0.090，95％CI （-0.029，1.143）]。제요추、전자간BMD이외，AA기인형군체적고골경、뇨골이급전신BMD고우VV기인형，단차기인형간비교적납입연구수량과소，증거상불충분。결론본Meta분석결과제시，동아인군중LRP5기인A1330V위점적돌변가능여골밀도적변화구유상관성，우기AA기인형인군재고골경、요추부위유비AV/VV혹VV기인형인군경고적골밀도치。단목전적결론상수진일보대양본、고질량적연구거험증。
Objective To evaluate the association of the A 1330V polymorphism of low-density lipoprotein receptor-related protein 5 (LRP5) gene and bone mineral density (BMD) in East-Asian population using Meta-analysis.Methods Pubmed, Embase, CNKI, and Wanfang database were all searched using a computer to collect studies on the association of the A 1330V polymorphism of LRP5 gene and BMD in East-Asian population.Related magazines were retrieved manually .The deadline was November 2012.The quality of the included studies was evaluated and the data were extracted .A Stata 12.0 software was used for Meta-analysis.Results A total of 11 studies were included in the present Meta-analysis, including 5906 subjects.The results of Meta-analysis showed that the Asian population with AA genotypes had higher BMD of the lumbar vertebrae than those with AV /VV genotypes [ SMD=0.107, 95%CI (0.044, 0.171)], and the difference was significant .BMD of the femur neck in subjects with AA genotypes was higher than that in subjects with AV/VV genotypes [SMD=0.190, 95%CI (0.034, 0.346)].BMD of the radius and the total skeleton in subjects with AA genotypes was higher than that in subjects with AV/VV genotypes .But no difference of BMD of the intertrochanteric femur between subjects with 2 genotypes [ SMD =0.090, 95%CI ( -0.029, 1.143)].Except for BMD of the lumbar vertebrae and the intertrochanteric femur, BMD of the hip, the femoral neck, and the total skeleton in subjects with AA genotypes was higher than that insubjects with VV genotypes.Owing the finite number of the included studies , statistical evidence was not enough.Conclusion Theresults of this Meta-analysis reveal that LRP5 A1330V polymorphism is associated with BMD, especially in subjects with AAgenotypes.BMD of the lumbar vertebrae and the femoral neck was higher than subjects with AA /VV or VV genotypes.This conclusionstill needs to be verified by further study with large amount of sample and high quality .