CAJ | 학술논문

目的：拟通过不同水质游泳运动对去卵巢雌性大鼠骨量及骨代谢相关激素影响的研究，为不同水质游泳运动预防绝经期骨质疏松症提供实验依据。方法将40只3月龄健康的雌性SD大鼠随机分为对照组、模型组、游泳一组和游泳二组共4组，每组各10只。除对照组外，其余各组行双侧卵巢切除术建立骨质疏松模型。造模成功后对按不同的方案对各组实验大鼠进行干预，其中游泳一组和游泳二组大鼠分别在淡水与海水溶液中游泳5周，每周5天，每天45分钟，对照组和模型组不进行游泳训练。干预后观察不同游泳运动对骨质疏松型大鼠股骨骨量、血清甲状旁腺激素（ PTH）及骨钙素（ BGP）水平的影响。结果游泳一组、游泳二组的游泳运动可使骨质疏松型大鼠骨量增加；同时使PTH水平下降、BGP水平升高，且淡水游泳训练与海水游泳训练结果比较有统计学差异。结论不同水质游泳运动可以调节钙调激素分泌释放，减慢伴随绝经期而发生的骨量丢失，起到预防绝经期骨质疏松的作用，且淡水游泳优于海水游泳。
목적：의통과불동수질유영운동대거란소자성대서골량급골대사상관격소영향적연구，위불동수질유영운동예방절경기골질소송증제공실험의거。방법장40지3월령건강적자성SD대서수궤분위대조조、모형조、유영일조화유영이조공4조，매조각10지。제대조조외，기여각조행쌍측란소절제술건립골질소송모형。조모성공후대안불동적방안대각조실험대서진행간예，기중유영일조화유영이조대서분별재담수여해수용액중유영5주，매주5천，매천45분종，대조조화모형조불진행유영훈련。간예후관찰불동유영운동대골질소송형대서고골골량、혈청갑상방선격소（ PTH）급골개소（ BGP）수평적영향。결과유영일조、유영이조적유영운동가사골질소송형대서골량증가；동시사PTH수평하강、BGP수평승고，차담수유영훈련여해수유영훈련결과비교유통계학차이。결론불동수질유영운동가이조절개조격소분비석방，감만반수절경기이발생적골량주실，기도예방절경기골질소송적작용，차담수유영우우해수유영。
Objective To observe the effect of swimming in different water on bone mass and serum level of bone metabolic related hormones in osteoporosis rats, and to provide experimental basis for the prevention of menopausal osteoporosis .Methods Forty 3-month healthy female SD rats were randomly divided into 4 groups (n =10): control group, osteoporosis group, swimming group 1,and swimming group 2.Except for the rats in control group, all the rats were ovariectomized for the establishment of osteoporosismodel.After successful establishment of osteoporosis model , rats in each group were intervened with different treatments .Rats inswimming group 1 and swimming group 2 conducted a swimming exercise in fresh water and sea water , respectively, for 45 minutes perday, 5 days per week, and the whole treatment lasted for 5 months.Rats in control group and osteoporosis group did not conduct anyswimming exercise.The effect of swimming in different water on bone mass of the femur and serum levels of PTH and BGP wasobserved.Results The bone mass of the rats in swimming group 1 and swimming group 2 increased, while the serum level of PTHdecreased and the serum level of BGP increased .And the results of rats swam in fresh water and sea water showed significant difference.Conclusion Swimming in different water can regulate the secretion and release of calcium -related hormones, reduce theloss of bone mass in menopause , and play an important role in the prevention of menopausal osteoporosis .And the results of swimmingin fresh water are better than those of swimming in sea water .