CAJ | 학술논문

骨质疏松症（ Osteoporosis ）是一种全身性的骨代谢障碍性疾病，以骨量减少，骨微结构退化，骨脆性增加，易发生骨折为特征的全身性疾病。随着社会逐渐进入老龄化，骨质疏松症也日趋成为影响健康的主要疾病，对骨质疏松治疗方面的研究就显得更加重要了。对骨质疏松症的更进一步研究发现骨髓间充质干细胞（ BMSC ）的衰老也是骨质疏松的发病机制之一。骨髓间充质干细胞（ BMSC）是多能的干细胞，即能够自我更新并分化成多种细胞类型，包括脂肪细胞、成骨细胞、软骨细胞。BMSC的植入能够有效增加局部骨量，提高骨密度，改善局部骨质疏松情况，可纠正骨代谢失衡，减少骨量丢失，增加成骨，为局部骨质疏松的治疗提供了一种新方法。
골질소송증（ Osteoporosis ）시일충전신성적골대사장애성질병，이골량감소，골미결구퇴화，골취성증가，역발생골절위특정적전신성질병。수착사회축점진입노령화，골질소송증야일추성위영향건강적주요질병，대골질소송치료방면적연구취현득경가중요료。대골질소송증적경진일보연구발현골수간충질간세포（ BMSC ）적쇠로야시골질소송적발병궤제지일。골수간충질간세포（ BMSC）시다능적간세포，즉능구자아경신병분화성다충세포류형，포괄지방세포、성골세포、연골세포。BMSC적식입능구유효증가국부골량，제고골밀도，개선국부골질소송정황，가규정골대사실형，감소골량주실，증가성골，위국부골질소송적치료제공료일충신방법。
Osteoporosis is a systemic disorder of bone metabolism , characterized by bone loss , bone microstructure degradation , increased bone fragility , and increased risks of bone fractures .With the aging of the population , osteoporosis increasingly becomes the main disease affecting health .So the study of osteoporosis treatment becomes more important .Further research of osteoporosis reveals that the senescence of bone marrow stem cells ( BMSCs ) is also a possible pathogenesis of osteoporosis .BMSCs are pluripotent stem cells, which are capable of self-renewal and differentiation into various cell types , including fat cells, osteoblasts, and cartilage cells. Implantation of BMSCs can effectively increase the local bone mass , increase the bone mineral density , and improve the local situation of osteoporosis.Hence, it can correct bone metabolic imbalance , reduce bone loss, and increase osteogenesis, which can provide a new method for the treatment of regional osteoporosis .