北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2013年
12期
60-61,62
,共3页
心绞痛%冠状动脉%斑块%心腔内超声
心絞痛%冠狀動脈%斑塊%心腔內超聲
심교통%관상동맥%반괴%심강내초성
Angina pectoris%Coronary artery%Plaque%Intravascular ultrasound
目的:早期识别不稳定斑块对于预防急性冠脉事件非常重要。目前使用先进的虚拟组织学冠状动脉内超声来研究冠状动脉斑块组分,并研究冠心病临床表现与非罪犯血管节段的斑块组分的临床联系。方法:对91例患者实施了虚拟冠状动脉内超声检查,检查的血管是狭窄小于50%的非罪犯病变的血管节段,其中,48例急性冠脉综合症患者,43例稳定心绞痛患者。结果:急性冠脉综合症患者组较稳定心绞痛患者组有着较高的钙化成分(7.86%±1.0%vs 4.9%±0.9%,P=0.03)和较高的坏死核心成分(13.6%±1.1%vs 8.4%±1.1%,P=0.001)。急性冠脉综合症患者组较稳定心绞痛患者组有着较高的薄帽纤维粥瘤(VH-TCFA)检出率(63.5%versus 34.8%,P=0.007)。在急性冠脉综合症患者中,检出薄帽纤维粥瘤(VH-TCFA)的患者的高敏C反应蛋白水平高于未检出薄帽纤维粥瘤(VH-TCFA)的患者(7.96±2.56mg/l vs 1.65±0.35mg/l,P=0.005)。结论:在非罪犯病变的冠状动脉节段,急性冠脉综合症患者组有着较高的薄帽纤维粥瘤(VH-TCFA)的发生率。在急性冠脉综合症中,检出薄帽纤维粥瘤(VH-TCFA)往往伴随有较高的高敏C反应蛋白水平。
目的:早期識彆不穩定斑塊對于預防急性冠脈事件非常重要。目前使用先進的虛擬組織學冠狀動脈內超聲來研究冠狀動脈斑塊組分,併研究冠心病臨床錶現與非罪犯血管節段的斑塊組分的臨床聯繫。方法:對91例患者實施瞭虛擬冠狀動脈內超聲檢查,檢查的血管是狹窄小于50%的非罪犯病變的血管節段,其中,48例急性冠脈綜閤癥患者,43例穩定心絞痛患者。結果:急性冠脈綜閤癥患者組較穩定心絞痛患者組有著較高的鈣化成分(7.86%±1.0%vs 4.9%±0.9%,P=0.03)和較高的壞死覈心成分(13.6%±1.1%vs 8.4%±1.1%,P=0.001)。急性冠脈綜閤癥患者組較穩定心絞痛患者組有著較高的薄帽纖維粥瘤(VH-TCFA)檢齣率(63.5%versus 34.8%,P=0.007)。在急性冠脈綜閤癥患者中,檢齣薄帽纖維粥瘤(VH-TCFA)的患者的高敏C反應蛋白水平高于未檢齣薄帽纖維粥瘤(VH-TCFA)的患者(7.96±2.56mg/l vs 1.65±0.35mg/l,P=0.005)。結論:在非罪犯病變的冠狀動脈節段,急性冠脈綜閤癥患者組有著較高的薄帽纖維粥瘤(VH-TCFA)的髮生率。在急性冠脈綜閤癥中,檢齣薄帽纖維粥瘤(VH-TCFA)往往伴隨有較高的高敏C反應蛋白水平。
목적:조기식별불은정반괴대우예방급성관맥사건비상중요。목전사용선진적허의조직학관상동맥내초성래연구관상동맥반괴조분,병연구관심병림상표현여비죄범혈관절단적반괴조분적림상련계。방법:대91례환자실시료허의관상동맥내초성검사,검사적혈관시협착소우50%적비죄범병변적혈관절단,기중,48례급성관맥종합증환자,43례은정심교통환자。결과:급성관맥종합증환자조교은정심교통환자조유착교고적개화성분(7.86%±1.0%vs 4.9%±0.9%,P=0.03)화교고적배사핵심성분(13.6%±1.1%vs 8.4%±1.1%,P=0.001)。급성관맥종합증환자조교은정심교통환자조유착교고적박모섬유죽류(VH-TCFA)검출솔(63.5%versus 34.8%,P=0.007)。재급성관맥종합증환자중,검출박모섬유죽류(VH-TCFA)적환자적고민C반응단백수평고우미검출박모섬유죽류(VH-TCFA)적환자(7.96±2.56mg/l vs 1.65±0.35mg/l,P=0.005)。결론:재비죄범병변적관상동맥절단,급성관맥종합증환자조유착교고적박모섬유죽류(VH-TCFA)적발생솔。재급성관맥종합증중,검출박모섬유죽류(VH-TCFA)왕왕반수유교고적고민C반응단백수평。
Objective:Early diagnosis on unstable plaque is very important for preventing acute coronary events. Currently, intravascular ultrasound (IVUS) has been clinically used to analysis coronary plaque. Method:91 patients including 48 patients with acute coronary syndrome (ACS) and 43 patients with stable angina pectoris (SAP), were included, and non-crime vessel with a stenosis less than 50% in these patients were assessed by IVUS. Results:Comparison with patients with SAP, patients with ACS had higher calcification scores(7.86%±1.0%vs 4.9%±0.9%,P=0.03), necrosis cores(13.6%±1.1% vs 8.4%±1.1%,P=0.001), and thin cap atheromatous plaque (63.5%versus 34.8%,P=0.007). In addition, C-reactive protein levels of thin cap atheromatous plaque in patients with ACS is higher than those in SAP (7.96±2.56 mg/l vs 1.65±0.35mg/l,P=0.005). Conclusion:Patients with ACS had higher thin cap atheromatous plaque and C-reactive protein levels.