药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2013年
5期
288
,共1页
刘培%任科雨%王艳婷%张炜%曹彬%魏良洲
劉培%任科雨%王豔婷%張煒%曹彬%魏良洲
류배%임과우%왕염정%장위%조빈%위량주
雷贝拉唑%药物性肝损伤
雷貝拉唑%藥物性肝損傷
뢰패랍서%약물성간손상
Rabeprazole%Drug-induced liver injury
1例45岁男性患者因反酸给予雷贝拉唑钠肠溶片10 mg,1次/d.3周后因症状加重自行加倍服药.3d后出现全身乏力、食欲减退、小便深黄.停用雷贝拉唑钠肠溶片.实验室检查:丙氨酸转氨酶401 U/L,天冬氨酸转氨酶314 U/L,碱性磷酸酶143 U/L,γ-L-谷氨酰转移酶359 U/L,总胆红素22.7 μmol/L.给予保肝治疗.1周后复查,丙氨酸转氨酶40 U/L,天冬氨酸转氨酶15 U/L.
1例45歲男性患者因反痠給予雷貝拉唑鈉腸溶片10 mg,1次/d.3週後因癥狀加重自行加倍服藥.3d後齣現全身乏力、食欲減退、小便深黃.停用雷貝拉唑鈉腸溶片.實驗室檢查:丙氨痠轉氨酶401 U/L,天鼕氨痠轉氨酶314 U/L,堿性燐痠酶143 U/L,γ-L-穀氨酰轉移酶359 U/L,總膽紅素22.7 μmol/L.給予保肝治療.1週後複查,丙氨痠轉氨酶40 U/L,天鼕氨痠轉氨酶15 U/L.
1례45세남성환자인반산급여뢰패랍서납장용편10 mg,1차/d.3주후인증상가중자행가배복약.3d후출현전신핍력、식욕감퇴、소편심황.정용뢰패랍서납장용편.실험실검사:병안산전안매401 U/L,천동안산전안매314 U/L,감성린산매143 U/L,γ-L-곡안선전이매359 U/L,총담홍소22.7 μmol/L.급여보간치료.1주후복사,병안산전안매40 U/L,천동안산전안매15 U/L.
A 45-year-old man received rabeprazole sodium enteric-coated tablets 10 mg once daily for acid regurgitation.Three week later,the symptom worsened,so he self-medicated double dosage.He developed generalized weakness,inappetence,dark yellow urine after 3 days.Rabeprazole sodium entericcoated tablets was stopped.Laboratory tests showed the following values:alanine aminotransferase 401 U/mL,aspartate aminotransferase 314 U/mL,alkaline phosphatase 143 U/mL,γ-glutamyl transferase 359 U/mL,total bilirubin 22.7 μmol/L.He was given liver protective drugs.One week later,the levels of alanine aminotransferase and aspartate aminotransferase were 40 U/L and 15 U/L,respectively.
