CAJ | 학술논문

目的：探讨地佐辛用于老年人纤维结肠镜检查对于依托咪酯麻醉半数有效剂量的影响。方法：本院择期行全麻下纤维结肠镜检查术、ASAⅠ-Ⅱ级、年龄65—75岁老年患者60例，随机均分为地佐辛组和对照组。检查前地佐辛组给予地佐辛5mg，对照组给予等容量生理盐水，5min 后依托咪酯按预试验结果0.04mg/kg,0.06mg/kg,0.09mg/kg,0.130mg/kg序贯给药，对照组按0.06mg/kg,0.09mg/kg,0.130mg/kg，0.20mg/kg序贯给药，20s恒速输注完毕，采用序贯法测定两组半数有效剂量（ED50）。结果：两组一般情况差异无统计学意义（P>0.05）。地佐辛组和对照组的ED50分别为0.085mg/kg,0.102mg/kg。结论：地佐辛联合依托咪酯用于老年人纤维结肠镜检查安全有效，地佐辛可以有效降低依托咪酯ED50。
목적：탐토지좌신용우노년인섬유결장경검사대우의탁미지마취반수유효제량적영향。방법：본원택기행전마하섬유결장경검사술、ASAⅠ-Ⅱ급、년령65—75세노년환자60례，수궤균분위지좌신조화대조조。검사전지좌신조급여지좌신5mg，대조조급여등용량생리염수，5min 후의탁미지안예시험결과0.04mg/kg,0.06mg/kg,0.09mg/kg,0.130mg/kg서관급약，대조조안0.06mg/kg,0.09mg/kg,0.130mg/kg，0.20mg/kg서관급약，20s항속수주완필，채용서관법측정량조반수유효제량（ED50）。결과：량조일반정황차이무통계학의의（P>0.05）。지좌신조화대조조적ED50분별위0.085mg/kg,0.102mg/kg。결론：지좌신연합의탁미지용우노년인섬유결장경검사안전유효，지좌신가이유효강저의탁미지ED50。