检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2013年
23期
3150-3152
,共3页
腹腔镜%肝癌%肝切除术%C-反应蛋白%凝血功能
腹腔鏡%肝癌%肝切除術%C-反應蛋白%凝血功能
복강경%간암%간절제술%C-반응단백%응혈공능
laparoscopy%liver cancer%liver resection%C-reactive protein%coagulation function
目的：探讨腹腔镜规则肝叶切除和开腹治疗原发性肝癌（HCC）的疗效及其对 C-反应蛋白（CRP）和凝血功能的影响。方法将56例 HCC 患者分为腹腔镜组和开腹组，每组各28例。比较两种手术方式的临床疗效及 CRP 和凝血功能指标的变化。结果腹腔镜组总有效率为89．28％，显著优于开腹组的42．86％，差异有统计学意义（P＜0．05）；术中腹腔镜组平均出血量、术后平均禁食时间、平均腹腔引流时间、平均住院时间、并发症发生率均明显少于开腹组，差异有统计学意义（P＜0．05）；术后两组患者的 CRP 、血小板计数、活化部分凝血活酶时间和凝血酶时间均呈现不同程度下降，差异有统计学意义（P ＜0．05）；腹腔镜组上述指标的改善程度明显优于与开腹组，差异有统计学意义（P＜0．05）；腹腔镜组1年生存率亦显著高于开腹组，差异有统计学意义（P ＜0．05）。结论与传统开腹手术相比，腹腔镜规则肝叶切除术是治疗 HCC 的有效微创方法，CRP 和凝血功能是其潜在的生物标志。
目的：探討腹腔鏡規則肝葉切除和開腹治療原髮性肝癌（HCC）的療效及其對 C-反應蛋白（CRP）和凝血功能的影響。方法將56例 HCC 患者分為腹腔鏡組和開腹組，每組各28例。比較兩種手術方式的臨床療效及 CRP 和凝血功能指標的變化。結果腹腔鏡組總有效率為89．28％，顯著優于開腹組的42．86％，差異有統計學意義（P＜0．05）；術中腹腔鏡組平均齣血量、術後平均禁食時間、平均腹腔引流時間、平均住院時間、併髮癥髮生率均明顯少于開腹組，差異有統計學意義（P＜0．05）；術後兩組患者的 CRP 、血小闆計數、活化部分凝血活酶時間和凝血酶時間均呈現不同程度下降，差異有統計學意義（P ＜0．05）；腹腔鏡組上述指標的改善程度明顯優于與開腹組，差異有統計學意義（P＜0．05）；腹腔鏡組1年生存率亦顯著高于開腹組，差異有統計學意義（P ＜0．05）。結論與傳統開腹手術相比，腹腔鏡規則肝葉切除術是治療 HCC 的有效微創方法，CRP 和凝血功能是其潛在的生物標誌。
목적：탐토복강경규칙간협절제화개복치료원발성간암（HCC）적료효급기대 C-반응단백（CRP）화응혈공능적영향。방법장56례 HCC 환자분위복강경조화개복조，매조각28례。비교량충수술방식적림상료효급 CRP 화응혈공능지표적변화。결과복강경조총유효솔위89．28％，현저우우개복조적42．86％，차이유통계학의의（P＜0．05）；술중복강경조평균출혈량、술후평균금식시간、평균복강인류시간、평균주원시간、병발증발생솔균명현소우개복조，차이유통계학의의（P＜0．05）；술후량조환자적 CRP 、혈소판계수、활화부분응혈활매시간화응혈매시간균정현불동정도하강，차이유통계학의의（P ＜0．05）；복강경조상술지표적개선정도명현우우여개복조，차이유통계학의의（P＜0．05）；복강경조1년생존솔역현저고우개복조，차이유통계학의의（P ＜0．05）。결론여전통개복수술상비，복강경규칙간협절제술시치료 HCC 적유효미창방법，CRP 화응혈공능시기잠재적생물표지。
Objective To explore the clinical efficiency of laparoscopic hepatectomy and laparotomy treatment with HCC and their impact on the C-reactive protein(CRP) and coagulation function .Methods Fifty six cases with HCC patients were divided into laparoscopic group and laparotomy group ,twenty eight cases in each group .Clinical efficacy ,CRP and coagulation indicators from the two groups were compared .Results The overall effective rate of Laparoscopic group was 89 .28% ,which was significantly better than 42 .86% of laparotomy group(P< 0 .05) ;Mean intraoperative blood loss ,postoperative mean fasting time ,average peritoneal drainage time ,average length of stay ,in-cidence of complications were significantly less than the laparotomy group (P< 0 .05) ;The CRP ,PLT ,APTT and TT indicators in two groups were declined after surgery (P< 0 .05) ;The degree of improvement of these indicators in lap-aroscopic group was significantly better than laparotomy group ( P < 0 .05) ;One-year survival rate of laparoscopic group was also significantly higher than the laparotomy group (P< 0 .05) .Conclusion Compared with the traditional laparotomy ,laparoscopic hepatectomy is an effective minimally invasive approach for the treatment of HCC ,and CRP and coagulation parameters could be its potential biomarkers .
