CAJ | 학술논문

目的：检测结核性胸膜炎患者血清中白细胞介素-2受体（IL-2R）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）浓度的变化，探讨三者与结核性胸膜炎临床表现的相互关系及其临床意义。方法采用酶联免疫吸附试验对50例结核性胸膜炎患者（实验组）治疗前后以及40例健康体检者（对照组）血清 IL-2R 、TNF-α和 PCT 浓度进行检测。结果结核性胸膜炎患者血清中 IL-2R 、TNF-α和 PCT 浓度显著高于对照组，差异有统计学意义（P ＜0．01）；治疗后恢复期三者浓度明显下降，但仍高于对照组，差异无统计学意义（P＞0．05）。结论 IL-2R 、TNF-α和PCT 在结核性胸膜炎的发生和发展过程中起重要作用，可以作为诊断结核性胸膜炎的重要依据之一，对结核性胸膜炎的临床治疗和预后也有一定临床实用价值。
목적：검측결핵성흉막염환자혈청중백세포개소-2수체（IL-2R）、종류배사인자-α（TNF-α）、강개소원（PCT）농도적변화，탐토삼자여결핵성흉막염림상표현적상호관계급기림상의의。방법채용매련면역흡부시험대50례결핵성흉막염환자（실험조）치료전후이급40례건강체검자（대조조）혈청 IL-2R 、TNF-α화 PCT 농도진행검측。결과결핵성흉막염환자혈청중 IL-2R 、TNF-α화 PCT 농도현저고우대조조，차이유통계학의의（P ＜0．01）；치료후회복기삼자농도명현하강，단잉고우대조조，차이무통계학의의（P＞0．05）。결론 IL-2R 、TNF-α화PCT 재결핵성흉막염적발생화발전과정중기중요작용，가이작위진단결핵성흉막염적중요의거지일，대결핵성흉막염적림상치료화예후야유일정림상실용개치。
Objective To investigate the changes of concentration of interlukin-2 receptor(IL-2R) ,tumor nec-rosis factor-α(TNF-α) and procalcitonin(PCT ) in patients with tuberculous pleurisy ,to explore the relationship be-tween these detections with clinical symtoms .Methods Fifty patients diagnosed as tuberculous pleurisy were chosen as test group ,and the serum concentrations of IL-2R ,TNF-α and PCT in these patients were measured by the method of enzyme - linked immunosobent assay(ELISA) ,both before and after the treatment .Forty healthy people were cho-sen as control group ,and their serum concentrations of IL-2R ,TNF-α and PCT were also detected by ELISA .Results The serum concentrations of IL-2R ,TNF-α and PCT in patients with tuberculous pleurisy before treatment were sig-nificantly higher than those in normal control group(P< 0 .01) ;after the treatment ,there was no difference in the se-rum concentrations of IL-2R ,TNF-α and PCT between these patients in experimental group and those in healthy con-trol group(P> 0 .05) .Conclusion IL-2R ,TNF-αand PCT play an important role in the pathogenesis of tuberculous pleurisy ,and they could be one of the most important diagnostic evidences ,and they also have clinical values for the treatment and prognosis of this disease .