CAJ | 학술논문

目的：探讨甲胎蛋白异质体检测在肝癌诊断中的价值。方法选取1052例甲胎蛋白（AFP）≥20 ng/mL 的患者，取血清，采用凝集素亲和免疫电泳法检测 AFP 异质体。结果肝癌患者 AFP-L3比值高于良性慢性肝病患者，AFP-L3/AFP ＞35％时诊断特异度较高。结论 AFP 异质体检测在高 AFP 人群中具有重要的肝癌诊断意义，但还需结合其他手段长期监测。
목적：탐토갑태단백이질체검측재간암진단중적개치。방법선취1052례갑태단백（AFP）≥20 ng/mL 적환자，취혈청，채용응집소친화면역전영법검측 AFP 이질체。결과간암환자 AFP-L3비치고우량성만성간병환자，AFP-L3/AFP ＞35％시진단특이도교고。결론 AFP 이질체검측재고 AFP 인군중구유중요적간암진단의의，단환수결합기타수단장기감측。
Objective To discuss the utility of α-fetoprotein heterogeneity in the diagnosis of liver cancer . Methods Serum obtained from 1 052 patients with serum α-fetoprotein ≥ 20 ng/mL .Lectin affinity electrophoresis was used to test the contents of AFP heterogeneity .Results The proportion of α-fetoprotein-L3 with liver cancer patients was significantly higher than that in the benign chronic liver disease patients .There were got a high speci-ficity when AFP-L3/AFP > 35% .Conclusion It's has a important significance of α- fetoprotein heterogeneity detec-tion .meanwhile ,other means should be adopted .