中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
11期
39-40
,共2页
脑卒中后抑郁%急性和慢性期缺血性脑卒中患者抑郁障碍%文拉法辛
腦卒中後抑鬱%急性和慢性期缺血性腦卒中患者抑鬱障礙%文拉法辛
뇌졸중후억욱%급성화만성기결혈성뇌졸중환자억욱장애%문랍법신
Post stroke depression%Depressive disorder after acute or chronic ischemic stroke%Venlafaxine
目的：比较文拉法辛治疗脑卒中后急性和慢性期缺血性脑卒中患者抑郁障碍治疗的疗效。方法选择2010-2013门诊及病房收治的脑梗死患者为观察对象。急性组为首次发病住院，脑卒中后即日至2个月的缺血性脑卒中患者60例，慢性组为脑卒中后3个月~1年的缺血性脑卒中患者60例，均符合中华医学会第四届全国脑血管会议修订的《脑血管病诊断要点》及《中国精神障碍诊断和分类标准(CCMD-3)》抑郁诊断标准，HAMD抑郁量表评分>18分。观察疗程均为8周，定期对患者采用HAMD抑郁量表比较，采用χ2检验。结果急性组临床疗效总有效率为90.0％，显著优于对照组的73.0％(P<0．05)。两组治疗后HAMD评定，治疗第2周开始较治疗前有统计学意义，且一直持续至观察第8周，急性组较慢性组差异有统计学意义(P<0.05)。结论文拉法辛治疗脑卒中后抑郁急性较慢性期缺血性脑卒中患者抑郁障碍治疗疗效显著。
目的：比較文拉法辛治療腦卒中後急性和慢性期缺血性腦卒中患者抑鬱障礙治療的療效。方法選擇2010-2013門診及病房收治的腦梗死患者為觀察對象。急性組為首次髮病住院，腦卒中後即日至2箇月的缺血性腦卒中患者60例，慢性組為腦卒中後3箇月~1年的缺血性腦卒中患者60例，均符閤中華醫學會第四屆全國腦血管會議脩訂的《腦血管病診斷要點》及《中國精神障礙診斷和分類標準(CCMD-3)》抑鬱診斷標準，HAMD抑鬱量錶評分>18分。觀察療程均為8週，定期對患者採用HAMD抑鬱量錶比較，採用χ2檢驗。結果急性組臨床療效總有效率為90.0％，顯著優于對照組的73.0％(P<0．05)。兩組治療後HAMD評定，治療第2週開始較治療前有統計學意義，且一直持續至觀察第8週，急性組較慢性組差異有統計學意義(P<0.05)。結論文拉法辛治療腦卒中後抑鬱急性較慢性期缺血性腦卒中患者抑鬱障礙治療療效顯著。
목적：비교문랍법신치료뇌졸중후급성화만성기결혈성뇌졸중환자억욱장애치료적료효。방법선택2010-2013문진급병방수치적뇌경사환자위관찰대상。급성조위수차발병주원，뇌졸중후즉일지2개월적결혈성뇌졸중환자60례，만성조위뇌졸중후3개월~1년적결혈성뇌졸중환자60례，균부합중화의학회제사계전국뇌혈관회의수정적《뇌혈관병진단요점》급《중국정신장애진단화분류표준(CCMD-3)》억욱진단표준，HAMD억욱량표평분>18분。관찰료정균위8주，정기대환자채용HAMD억욱량표비교，채용χ2검험。결과급성조림상료효총유효솔위90.0％，현저우우대조조적73.0％(P<0．05)。량조치료후HAMD평정，치료제2주개시교치료전유통계학의의，차일직지속지관찰제8주，급성조교만성조차이유통계학의의(P<0.05)。결논문랍법신치료뇌졸중후억욱급성교만성기결혈성뇌졸중환자억욱장애치료료효현저。
Objective To compare the therapeutic effect of venlafaxine on patients with depressive disorder (DD) after acute or chronic ischemic stroke. Methods The patients with cerebral infarction were selected from Department of Neurology and ward of The People's Hospital of Liaoning Province between 2010 and 2013. They were divided into acute group (60 patients, first episode with the course of disease was less than 2 months) and chronic group (60 patients with the disease course of 3-12 months after stroke). The diagnosis of the patients conformed to Diagnostic Points for Cerebrovascular Disease and Chinese Classification and Diagnostic Criteria of Mental Disorders, Version Three (CCMD-3) revised by The Chinese Medical Association Fourth National Cerebrovascular Diseases Conference, with the scores of HAMD depression scale >18. All patients received the treatment of 8 weeks, and had regular evaluation with HAMD depression scale. X2-test was used in the comparison between the acute group and the chronic group. Results The clinical total effective rate was 90.0% in acute group, significantly higher than the control group's 73.0%(P<0.05). HAMD evaluation of two groups after treatment, treatment from the second week had statistical significance com-pared with pretreatment, and continued to the eighth week. There was statistical significance in acute group compared with chronic group (P<0.05). Conclusion Venlafaxine has significant curative effect on patients with depressive disorder after acute ischemic stroke compared with chronic ischemic stroke.
