中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2014年
2期
134-138
,共5页
俞小敏%肖洁%陈秀萌%何洁莹
俞小敏%肖潔%陳秀萌%何潔瑩
유소민%초길%진수맹%하길형
肾脏病%肾小球滤过率%炎症%肥大,左心室
腎髒病%腎小毬濾過率%炎癥%肥大,左心室
신장병%신소구려과솔%염증%비대,좌심실
Kidney diseases%Glomerular filtration rate%Inflammation%Hypertrophy,left ventricular
目的 探讨中晚期慢性肾脏病(CKD)患者肾功能、炎性因子与左心室肥厚(LVH)的关系.方法 以2009年1月至2012年12月本院收治或门诊就诊的中晚期CKD患者51例为研究对象,收集患者的临床与生化指标,超声检查测量患者左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)等指标并计算左心室质量指数(LVMI).根据肾小球滤过率(GFR)将患者分为CKD 3期组和CKD4期组,根据有或无LVH对患者分组,分别进行临床与生化指标、超声检查指标的组间比较.对患者的GFR与临床指标、生化指标和超声检查指标进行相关性分析.结果 51例CKD患者中,CKD3期32例、CKD4期19例,两组患者血清C反应蛋白、纤维蛋白原和白蛋白差异无统计学意义(均P>0.05);有LVH患者40例,无LVH患者11例,与无LVH组比较,有LVH组患者血清C反应蛋白、纤维蛋白原升高,白蛋白降低(均P< 0.05).中晚期CKD患者GFR与LVEF、LVFS呈正相关(r=0.398、0.394,均P<0.05).结论 中晚期CKD患者血清C反应蛋白和纤维蛋白原升高可能预示LVH发生,患者肾功能与左室收缩功能有关联.
目的 探討中晚期慢性腎髒病(CKD)患者腎功能、炎性因子與左心室肥厚(LVH)的關繫.方法 以2009年1月至2012年12月本院收治或門診就診的中晚期CKD患者51例為研究對象,收集患者的臨床與生化指標,超聲檢查測量患者左心室射血分數(LVEF)、左心室短軸縮短率(LVFS)等指標併計算左心室質量指數(LVMI).根據腎小毬濾過率(GFR)將患者分為CKD 3期組和CKD4期組,根據有或無LVH對患者分組,分彆進行臨床與生化指標、超聲檢查指標的組間比較.對患者的GFR與臨床指標、生化指標和超聲檢查指標進行相關性分析.結果 51例CKD患者中,CKD3期32例、CKD4期19例,兩組患者血清C反應蛋白、纖維蛋白原和白蛋白差異無統計學意義(均P>0.05);有LVH患者40例,無LVH患者11例,與無LVH組比較,有LVH組患者血清C反應蛋白、纖維蛋白原升高,白蛋白降低(均P< 0.05).中晚期CKD患者GFR與LVEF、LVFS呈正相關(r=0.398、0.394,均P<0.05).結論 中晚期CKD患者血清C反應蛋白和纖維蛋白原升高可能預示LVH髮生,患者腎功能與左室收縮功能有關聯.
목적 탐토중만기만성신장병(CKD)환자신공능、염성인자여좌심실비후(LVH)적관계.방법 이2009년1월지2012년12월본원수치혹문진취진적중만기CKD환자51례위연구대상,수집환자적림상여생화지표,초성검사측량환자좌심실사혈분수(LVEF)、좌심실단축축단솔(LVFS)등지표병계산좌심실질량지수(LVMI).근거신소구려과솔(GFR)장환자분위CKD 3기조화CKD4기조,근거유혹무LVH대환자분조,분별진행림상여생화지표、초성검사지표적조간비교.대환자적GFR여림상지표、생화지표화초성검사지표진행상관성분석.결과 51례CKD환자중,CKD3기32례、CKD4기19례,량조환자혈청C반응단백、섬유단백원화백단백차이무통계학의의(균P>0.05);유LVH환자40례,무LVH환자11례,여무LVH조비교,유LVH조환자혈청C반응단백、섬유단백원승고,백단백강저(균P< 0.05).중만기CKD환자GFR여LVEF、LVFS정정상관(r=0.398、0.394,균P<0.05).결론 중만기CKD환자혈청C반응단백화섬유단백원승고가능예시LVH발생,환자신공능여좌실수축공능유관련.
Objective To investigate the association of renal function and inflammatory cytokines with left ventricular hypertrophy (LVH) in patients with intermediate or advanced stage chronic kidney disease (CKD).Methods Fifty-one hospitalized or clinic patients with intermediate or advanced stage CKD registered to our hospital between January 2009 and December 2012 were enrolled.Clinical and biochemical data of these patients were recorded.Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of these patients were measured with ultrasonography and used for calculation of left ventricular mass index (LVMI).The patients were then divided into stage Ⅲ CKD group or stage Ⅳ CKD group according to glomerular filtration rate (GFR),and also into LVH group and non-LVH group according to presence of LVH.Clinical and biochemical data,as well as findings of ultrasonography were compared between these groups.The correlation between GFR and the clinical and biochemical data,ultrasonic findings were analyzed.Results Of all 51 CKD patients,32 were stage Ⅲ CKD,and 19 stage Ⅳ CKD.There were no statistical difference in serum C-reactive protein (CRP),fibrinogen and albumin between patients with stage Ⅲ and stage Ⅳ CKD (all P>0.05).A total of 40 patients had LVH and the remaining 11 did not.Compared with non-LVH group,patients in LVH group had higher levels of serum CRP and fibrinogen,and lower level of serum albumin (all P < 0.05).In intermediate or advanced stage CKD patients,GFR correlated positively with LVEF and LVFS (r=0.398 and 0.394,respectively,both P < 0.05).Conclusions In patients with intermediate or advanced CKD,higher levels of serum CRP and fibrinogen may predict the occurrence of LVH.The renal function in those patients is associated with left ventricular systolic function.