中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
5期
745-747
,共3页
接活跌打膏%抗炎作用%镇痛作用
接活跌打膏%抗炎作用%鎮痛作用
접활질타고%항염작용%진통작용
Jiehuo dieda ointment%anti-inflammatory effects%Analgesia effects
目的：考察接活跌打膏的抗炎及镇痛作用。方法：采用角叉菜胶致大鼠足趾肿胀法、棉球致大鼠肉芽肿法观察接活跌打膏的抗炎作用；小鼠热板法和小鼠醋酸扭体法观察接活跌打膏的镇痛作用。结果：和模型组比较,在给药后2 h,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组可显著抑制角叉菜胶致大鼠足趾肿胀(P<0.05)；和正常对照组比较,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组能抑制大鼠棉球肉芽组织干重(P<0.05)；和正常对照组比较,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组能显著减少醋酸引起的小鼠扭体反应次数,在给药后60 min,能延长小鼠热板痛阈值( P<0.05或P<0.01)。结论：接活跌打膏具有显著的抗炎和镇痛作用。
目的：攷察接活跌打膏的抗炎及鎮痛作用。方法：採用角扠菜膠緻大鼠足趾腫脹法、棉毬緻大鼠肉芽腫法觀察接活跌打膏的抗炎作用；小鼠熱闆法和小鼠醋痠扭體法觀察接活跌打膏的鎮痛作用。結果：和模型組比較,在給藥後2 h,接活跌打膏28 g·kg-1和14 g·kg-1藥材劑量組可顯著抑製角扠菜膠緻大鼠足趾腫脹(P<0.05)；和正常對照組比較,接活跌打膏28 g·kg-1和14 g·kg-1藥材劑量組能抑製大鼠棉毬肉芽組織榦重(P<0.05)；和正常對照組比較,接活跌打膏28 g·kg-1和14 g·kg-1藥材劑量組能顯著減少醋痠引起的小鼠扭體反應次數,在給藥後60 min,能延長小鼠熱闆痛閾值( P<0.05或P<0.01)。結論：接活跌打膏具有顯著的抗炎和鎮痛作用。
목적：고찰접활질타고적항염급진통작용。방법：채용각차채효치대서족지종창법、면구치대서육아종법관찰접활질타고적항염작용；소서열판법화소서작산뉴체법관찰접활질타고적진통작용。결과：화모형조비교,재급약후2 h,접활질타고28 g·kg-1화14 g·kg-1약재제량조가현저억제각차채효치대서족지종창(P<0.05)；화정상대조조비교,접활질타고28 g·kg-1화14 g·kg-1약재제량조능억제대서면구육아조직간중(P<0.05)；화정상대조조비교,접활질타고28 g·kg-1화14 g·kg-1약재제량조능현저감소작산인기적소서뉴체반응차수,재급약후60 min,능연장소서열판통역치( P<0.05혹P<0.01)。결론：접활질타고구유현저적항염화진통작용。
Objective:To study the anti-inflammatory and analgesic effects of Jiehuo Dieda ointment. Methods:The anti-inflam-matory activity was observed by rat foot swelling model induced by carrageenan and rat cotton ball granuloma model, and writhing re-sponse in mice induced by acetic acid and hot-plate test were used to explore the analgesic effects. Results:Compared with that of mod-el group, Jiehuo Dieda ointment 28 g·kg-1 ,14 g·kg-1 could significantly decrease rats hind paw swelling rate after 2 hours of ad-ministration. Compared with that of normal control group,Jiehuo Dieda ointment 28 g·kg-1 ,14 g·kg-1 could significantly decrease the weights of rats cotton ball granuloma,could significantly decrease the writhing times ,and increase the pain thresholdr after 60 min of administration(P<0. 05,P<0. 01). Conclusion:Jiehuo Dieda Ointment had obviously anti-inflammatory and analgesia effects.
