CAJ | 학술논문

目的：探讨γ谷氨酰羧化酶（GGCX）（rs6738645）基因型在中国汉族人群中的分布情况，以及其基因多态性与瓣膜置换术后华法林稳定剂量的相关性。方法采用Snapshot技术检测228例研究对象GGCX（rs6738645）位点基因型，研究其基因型及等位基因频率；比较其中176例瓣膜置换术患者基因多态性与华法林稳定剂量的相关性。结果228例研究对象中，GGCX （rs6738645）位点基因型T T、GT、GG分别为84例（36．84％）、122例（53．51％）、22例（9．65％），T和G等位基因的频率分别为63．60％和36．40％；176例瓣膜置换术后患者服用华法林达稳定状态，华法林日维持剂量GG组低于T T、G T组，组间比较差异有统计学意义（P＜0．01）；基因型3组间国际标准化比值（INR）、凝血酶原时间（PT ）比较，差异无统计学意义（P＞0．05）。结论中国汉族人群GGCX （rs6738645）基因多态性可能是瓣膜置换术后华法林个体剂量差异的影响因素。
목적：탐토γ곡안선최화매（GGCX）（rs6738645）기인형재중국한족인군중적분포정황，이급기기인다태성여판막치환술후화법림은정제량적상관성。방법채용Snapshot기술검측228례연구대상GGCX（rs6738645）위점기인형，연구기기인형급등위기인빈솔；비교기중176례판막치환술환자기인다태성여화법림은정제량적상관성。결과228례연구대상중，GGCX （rs6738645）위점기인형T T、GT、GG분별위84례（36．84％）、122례（53．51％）、22례（9．65％），T화G등위기인적빈솔분별위63．60％화36．40％；176례판막치환술후환자복용화법림체은정상태，화법림일유지제량GG조저우T T、G T조，조간비교차이유통계학의의（P＜0．01）；기인형3조간국제표준화비치（INR）、응혈매원시간（PT ）비교，차이무통계학의의（P＞0．05）。결론중국한족인군GGCX （rs6738645）기인다태성가능시판막치환술후화법림개체제량차이적영향인소。
Objective To investigate the gamma glutamine carboxylase (GGCX ,rs6738645) genotype distribution in Chinese Han population and the correlation between GGCX (rs6738645) polymorphism and the warfarin stable dose in the patient after valve replacement .Methods The genotypes of 228 cases were detected by the Snapshot technology in order to explore the genotype and allele frequencies .The correlation between the gene polymorphism in 176 cases after valve replacement and the stable dose of warfa-rin was compared .Results In total of 228 research subjects ,the number of TT ,GT and GG genotype were 84(36 .84% ) ,122 (53 .51% ) and 22(9 .65% ) .The frequencies of T and G allele were 63 .60% and 36 .40% respectively ;in 176 patients after the valve replacement ,the maintenance stable dose of warfarin was lower in GG group than in the TT and GT groups ,the differences between the groups showed statistical significance (P<0 .01) .The PT value and INR value had no statistical difference among 3 genotype groups(P>0 .05) .Conclusion The GGCX(rs6738645) polymorphism in Chinese Han population may be the influencing factor of warfarin individual dose difference in the patients after valve replacement .