CAJ | 학술논문

P300/CBP是组蛋白乙酰转移酶（ HAT）中重要的大分子蛋白之一，P300/CBP具有高度的同源性，虽然由不同的基因编码，但因其有相近的氨基酸排序和功能，而且又属于同一类的蛋白质，所以经常把它们写为P300/CBP。 P300/CBP参与了很多种转录因子的激活，它本身也存在着乙酰转移酶活性，能够乙酰化4种核心组蛋白和多种转录因子。越来越多的研究证实P300/CBP的变异与人类多种疾病，糖尿病，炎症、心脏病，特别是肿瘤的发病相关，P300/CBP在肿瘤中也与一些通路有相关性，而这些通路在肿瘤中扮演着不同的角色。 P300/CBP虽然通常被看做是肿瘤抑制因子，但是在不同的肿瘤中P300/CBP也起着不同的作用，本文主要介绍了P300/CBP与一些实体肿瘤发病相关的基因之间的作用以及有关的转录因子和相关的转导通路。
P300/CBP시조단백을선전이매（ HAT）중중요적대분자단백지일，P300/CBP구유고도적동원성，수연유불동적기인편마，단인기유상근적안기산배서화공능，이차우속우동일류적단백질，소이경상파타문사위P300/CBP。 P300/CBP삼여료흔다충전록인자적격활，타본신야존재착을선전이매활성，능구을선화4충핵심조단백화다충전록인자。월래월다적연구증실P300/CBP적변이여인류다충질병，당뇨병，염증、심장병，특별시종류적발병상관，P300/CBP재종류중야여일사통로유상관성，이저사통로재종류중분연착불동적각색。 P300/CBP수연통상피간주시종류억제인자，단시재불동적종류중P300/CBP야기착불동적작용，본문주요개소료P300/CBP여일사실체종류발병상관적기인지간적작용이급유관적전록인자화상관적전도통로。
P300/CBP is one of the most important high molecular weight protein histone acetyltransferase ( HAT) Although it is encoded by multiple different genes , P300/CBP is highly homologous , Because they have the similar amino acid sequence and functions ,and belong to the same class of proteins ,normolly they are all called P300/CBP.P300/CBP is involved in the activation of many kinds of transcription factors ,the protein itself alsohas acetyltransferase activity ,and is capable of acetylation of 4 core histones and transcription factor .More and more studies have confirmed the relationship of P 300/CBP variation withmultiple human diseases , including in-flammation,diabetes,heart disease and especially cancer .In tumor P300/CBP is associated with some pathways , and these pathways play a different roles in the tumor .Although P300/CBP is usually regarded as a tumor sup-pressor factor ,is plays different roles in different tumors ,This review mainly introduces the relationship of P 300/CBP with some solid tumor disease genes ,related transcription factors and their signaling pathways .