CAJ | 학술논문

细菌耐药性是指细菌对于抗菌药物作用的耐受性。细菌耐药性的形成，是细菌进化发展的结果，是细菌适应性的表现，但它却给养殖业的发展和人类的健康带来威胁。本文首先综述了水产动物源细菌耐药性研究现状，主要包括质粒介导的水产动物源细菌耐药性、细菌耐药基因、细菌耐药性遗传学机制等；其次，从病原菌耐药性会导致水产疾病流行爆发和水产细菌耐药性对人类公共卫生安全的影响两方面，分析了水产动物源细菌耐药性的危害；最后，从合理、规范用药，加快水产疫苗和新型抗菌药物替代品的研制与应用，加强水产动物致病菌耐药性监测等方面，提出了预防和控制水产动物源细菌耐药性的对策和措施。
세균내약성시지세균대우항균약물작용적내수성。세균내약성적형성，시세균진화발전적결과，시세균괄응성적표현，단타각급양식업적발전화인류적건강대래위협。본문수선종술료수산동물원세균내약성연구현상，주요포괄질립개도적수산동물원세균내약성、세균내약기인、세균내약성유전학궤제등；기차，종병원균내약성회도치수산질병류행폭발화수산세균내약성대인류공공위생안전적영향량방면，분석료수산동물원세균내약성적위해；최후，종합리、규범용약，가쾌수산역묘화신형항균약물체대품적연제여응용，가강수산동물치병균내약성감측등방면，제출료예방화공제수산동물원세균내약성적대책화조시。
Bacterial resistance is the ability of a disease-causing bacterium to resist being killed by antibiotics. The formation of bacterial resistance is the result of the development of bacterial evolution and the manifest of bacterial adaptability; however, it threatens the development of aquaculture and human health. Firstly, this paper summarized the research progress on the bacterial resistance in aquatic animals in recent years, including plasmid-mediated resistance of bacteria, resistance gene of bacterial isolates from aquatic animals, and the genetic mechanism of antibiotic resistance and so on. Secondly, the paper analyzed the harm of bacterial resistance, which included the pathogen of bacterial resistance that caused epidemics and the antibiotic resistance of bacterial isolates from aquatic animals that threatened public health. Finally, from rational and standardized use of drugs, speeding up the development and application of aquatic vaccines and new antimicrobial drugs alternatives, strengthening of the surveillance about pathogen isolates from aquatic animals and so on, the paper provided some valuable methods and strategies on the prevention and control for bacterial resistance in aquatic animals.