济宁学院学报
濟寧學院學報
제저학원학보
JOURNAL OF JINING UNIVERSITY
2012年
6期
25-29
,共5页
α-氰基丙烯酸酯%反应机理%活性
α-氰基丙烯痠酯%反應機理%活性
α-청기병희산지%반응궤리%활성
α - cyanoacrylates%mechanism%activities
α-氰基丙烯酸酯类化合物是一类抑制植物光合作用PSⅡ重要除草剂,近年又有研究相继发现其抗癌、杀菌等活性,有重要研究意义,本文主要以3-对三氟甲基苯胺-3-[(R/S-)-α-甲基苄胺]-2-氰基丙烯酸酯及其中间体的合成为基础,对相应化合物及其中间体通过表征确定了其立体构型,对该反应的合成机理给出了相应合理的解释.同时,发现该类化合物具有一定抗烟草花叶病毒活性及抗癌活性,值得关注.
α-氰基丙烯痠酯類化閤物是一類抑製植物光閤作用PSⅡ重要除草劑,近年又有研究相繼髮現其抗癌、殺菌等活性,有重要研究意義,本文主要以3-對三氟甲基苯胺-3-[(R/S-)-α-甲基芐胺]-2-氰基丙烯痠酯及其中間體的閤成為基礎,對相應化閤物及其中間體通過錶徵確定瞭其立體構型,對該反應的閤成機理給齣瞭相應閤理的解釋.同時,髮現該類化閤物具有一定抗煙草花葉病毒活性及抗癌活性,值得關註.
α-청기병희산지류화합물시일류억제식물광합작용PSⅡ중요제초제,근년우유연구상계발현기항암、살균등활성,유중요연구의의,본문주요이3-대삼불갑기분알-3-[(R/S-)-α-갑기변알]-2-청기병희산지급기중간체적합성위기출,대상응화합물급기중간체통과표정학정료기입체구형,대해반응적합성궤리급출료상응합리적해석.동시,발현해류화합물구유일정항연초화협병독활성급항암활성,치득관주.
α - Cyanoacrylate is a kind of important herbicide targeted in Photosystem PSⅡ.Started from cyano ethyl acetate, the intermediate and the title compounds of Ethyl 3 - [ (R/S) - 1 -phenylethylamino ] -3 - (4 - (trifluoromethyl) -phenylamino) -2 -cyanoacrylate were synthesized. Also three of the title compounds were characterized through Single crystal diffraction and found to be E - isomerism,its reaction mechanism was given. It was also found that they possess high bioaetivity against TMV and PC3 cells in a certain extent.