中国兽药杂志
中國獸藥雜誌
중국수약잡지
CHINESE JOURNAL OF VETERINARY DRUG
2012年
9期
18-21
,共4页
徐俊%曹芳元%徐敏%祝圆%邱银生
徐俊%曹芳元%徐敏%祝圓%邱銀生
서준%조방원%서민%축원%구은생
头孢噻呋钠%麻鸭%药代动力学%生物利用度
頭孢噻呋鈉%痳鴨%藥代動力學%生物利用度
두포새부납%마압%약대동역학%생물이용도
ceftiofur sodium%brown duck%pharmacokinetics%bioavailability
研究头孢噻呋钠在成年麻鸭体内的药动学特征及生物利用度,为兽医临床制定合理的给药方案提供科学依据。选取24只健康的成年麻鸭,随机分为3组,以2 mg/kg剂量分别单次肌内注射、静脉注射和内服头孢噻呋钠,采用HPLC法检测血药浓度,计算头孢噻呋的药动力学参数和肌注、内服的生物利用度。结果表明：静脉注射头孢噻呋钠后,血药浓度经时数据符合二室开放模型,主要动力学参数：t1/2α为（0.19±0.22）h,t1/2β为（3.64±0.22）h,Vd为（0.48±0.06）L/kg,CL为（0.07±0.01）L/（kg.h）,AUC为（27.09±2.84）μg/（mL.h）;肌内注射后,血药浓度经时数据符合二室开放模型,主要动力学参数：t1/2α为（0.38±0.02）h,t1/2β为（4.56±0.29）h,Tmax为（0.49±0.17）h,Cmax为（6.44±0.44）μg/mL,AUC为（26.88±0.49）μg/（mL.h）,生物利用度为99.22%;内服后,血药浓度经时数据符合二室开放模型,主要动力学参数：t1/2α为（0.77±0.14）h,t1/2β为（3.81±0.23）h,Tmax为（1.06±0.23）h,Cmax为（3.62±0.20）μg/mL,AUC为（21.47±0.44）μg/（mL.h）,生物利用度为79.25%。头孢噻呋钠在成年麻鸭体内吸收迅速,半衰期较长,肌注的生物利用度高,内服吸收良好。
研究頭孢噻呋鈉在成年痳鴨體內的藥動學特徵及生物利用度,為獸醫臨床製定閤理的給藥方案提供科學依據。選取24隻健康的成年痳鴨,隨機分為3組,以2 mg/kg劑量分彆單次肌內註射、靜脈註射和內服頭孢噻呋鈉,採用HPLC法檢測血藥濃度,計算頭孢噻呋的藥動力學參數和肌註、內服的生物利用度。結果錶明：靜脈註射頭孢噻呋鈉後,血藥濃度經時數據符閤二室開放模型,主要動力學參數：t1/2α為（0.19±0.22）h,t1/2β為（3.64±0.22）h,Vd為（0.48±0.06）L/kg,CL為（0.07±0.01）L/（kg.h）,AUC為（27.09±2.84）μg/（mL.h）;肌內註射後,血藥濃度經時數據符閤二室開放模型,主要動力學參數：t1/2α為（0.38±0.02）h,t1/2β為（4.56±0.29）h,Tmax為（0.49±0.17）h,Cmax為（6.44±0.44）μg/mL,AUC為（26.88±0.49）μg/（mL.h）,生物利用度為99.22%;內服後,血藥濃度經時數據符閤二室開放模型,主要動力學參數：t1/2α為（0.77±0.14）h,t1/2β為（3.81±0.23）h,Tmax為（1.06±0.23）h,Cmax為（3.62±0.20）μg/mL,AUC為（21.47±0.44）μg/（mL.h）,生物利用度為79.25%。頭孢噻呋鈉在成年痳鴨體內吸收迅速,半衰期較長,肌註的生物利用度高,內服吸收良好。
연구두포새부납재성년마압체내적약동학특정급생물이용도,위수의림상제정합리적급약방안제공과학의거。선취24지건강적성년마압,수궤분위3조,이2 mg/kg제량분별단차기내주사、정맥주사화내복두포새부납,채용HPLC법검측혈약농도,계산두포새부적약동역학삼수화기주、내복적생물이용도。결과표명：정맥주사두포새부납후,혈약농도경시수거부합이실개방모형,주요동역학삼수：t1/2α위（0.19±0.22）h,t1/2β위（3.64±0.22）h,Vd위（0.48±0.06）L/kg,CL위（0.07±0.01）L/（kg.h）,AUC위（27.09±2.84）μg/（mL.h）;기내주사후,혈약농도경시수거부합이실개방모형,주요동역학삼수：t1/2α위（0.38±0.02）h,t1/2β위（4.56±0.29）h,Tmax위（0.49±0.17）h,Cmax위（6.44±0.44）μg/mL,AUC위（26.88±0.49）μg/（mL.h）,생물이용도위99.22%;내복후,혈약농도경시수거부합이실개방모형,주요동역학삼수：t1/2α위（0.77±0.14）h,t1/2β위（3.81±0.23）h,Tmax위（1.06±0.23）h,Cmax위（3.62±0.20）μg/mL,AUC위（21.47±0.44）μg/（mL.h）,생물이용도위79.25%。두포새부납재성년마압체내흡수신속,반쇠기교장,기주적생물이용도고,내복흡수량호。
Pharmacokinetics and bioavailability of ceftiofur sodium in adult brown ducks were studied to provide a scientific basis for a reasonable clinical program.24 healthy adult brown ducks which had been divided into three group were respectively administrated of ceftiofur sodium(2 mg/kg) by intramuscular injection,intravenous injection and oral gavages.The drug concentrations in plasma of ducks in each group were detected with high-performance liquid chromatogram(HPLC),and the pharmacokinetic parameters and the bioavailability were analyzed with Drug and Statistics(DAS).The results showed that the drug concentration-time data of ceftiofur following intravenous injection administration was well described by a two-compartment open model.The main parameters were as follow:t1/2α=(0.19±0.22)h,t1/2β=(3.64±0.22)h,Vd=(0.48±0.06)L/kg,CL=(0.07±0.01)L/(kg·h),AUC=(27.09±2.84)μg/(mL·h).The drug concentration-time data of ceftiofur following intramuscular injection administration was well described by a two-compartment open model.The parameters were as follow:t1/2α=(0.38±0.02)h,t1/2β(4.56±0.29)h,Tmax=(0.49±0.17)h,Cmax=(6.44±0.44)μg/mL,AUC=(26.88±0.49)μg/(mL·h) and the bioavailability was 99.22%;The drug concentration-time data of ceftiofur following oral administration was well described by a two-compartment open model.The main parameters were as follow:t1/2α=(0.77±0.14)h,t1/2β=(3.81±0.23)h,Tmax=(1.06±0.23)h,Cmax=(3.62±0.20)μg/mL,AUC=(21.47±0.44)μg/(mL·h),and the bioavailability was 79.25%.These results showed that ceftiofur was rapidly absorbed and had a long half-time in brown ducks.Ceftiofur had a high rate of bioavailability by intramuscular injection and was well absorbed by oral administration.
