临床药物治疗杂志
臨床藥物治療雜誌
림상약물치료잡지
CLINICAL MEDICATION JOURNAL
2014年
6期
60-62
,共3页
甲巯咪唑%药物不良反应%多关节炎综合征
甲巰咪唑%藥物不良反應%多關節炎綜閤徵
갑구미서%약물불량반응%다관절염종합정
methimazole%adverse drug reaction%polyarthritis
1例23岁女性甲状腺功能亢进症患者接受甲巯咪唑(30mg?d-1)治疗6周后出现多发、游走性关节肿痛,查白细胞、C-反应蛋白水平升高,血沉增快,抗核抗体(ANA)1:320,抗中性粒细胞胞浆抗体(ANCA)、类风湿因子(RF)、抗链球菌溶血素O(ASO)阴性。停用甲巯咪唑1周后症状好转,1月后症状完全缓解,复查抗核抗体1:100。
1例23歲女性甲狀腺功能亢進癥患者接受甲巰咪唑(30mg?d-1)治療6週後齣現多髮、遊走性關節腫痛,查白細胞、C-反應蛋白水平升高,血沉增快,抗覈抗體(ANA)1:320,抗中性粒細胞胞漿抗體(ANCA)、類風濕因子(RF)、抗鏈毬菌溶血素O(ASO)陰性。停用甲巰咪唑1週後癥狀好轉,1月後癥狀完全緩解,複查抗覈抗體1:100。
1례23세녀성갑상선공능항진증환자접수갑구미서(30mg?d-1)치료6주후출현다발、유주성관절종통,사백세포、C-반응단백수평승고,혈침증쾌,항핵항체(ANA)1:320,항중성립세포포장항체(ANCA)、류풍습인자(RF)、항련구균용혈소O(ASO)음성。정용갑구미서1주후증상호전,1월후증상완전완해,복사항핵항체1:100。
A 23-year-old female with hyperthyroidism developed migratory polyarthritis 6 weeks after starting therapy with methimazole (30mg daily). Her clinical laboratory tests showed increased total white blood cel count, elevated C-reactive protein level and erythrocyte sedimentation rate and the level of antinuclear antibody (ANA) was 1:320. Test results were negative for the presence of anti-neutrophil cytoplasmic antibodies (ANCAs), rheumatoid factor (RF) and anti-streptolysin O (ASO). Her symptoms were improved 1 week after methimazole was withdrawn, and completely disappeared 1 month later. The test result of ANA analysis was 1:100.