CAJ | 학술논문

由于优异安全性和有效性数据，结合疫苗已成为细菌性疫苗研制的一个方向，但因不同团体独立研发，产生了不同的结合技术，也带来了一些困惑。通过对几个具有代表性的结合疫苗研发团队的研究历程的回顾，探讨了结合方法、载体蛋白质、剂型等热点话题，以期对结合疫苗的研制有所帮助。
유우우이안전성화유효성수거，결합역묘이성위세균성역묘연제적일개방향，단인불동단체독립연발，산생료불동적결합기술，야대래료일사곤혹。통과대궤개구유대표성적결합역묘연발단대적연구역정적회고，탐토료결합방법、재체단백질、제형등열점화제，이기대결합역묘적연제유소방조。
Due to the excellent safety and efficacy data , conjugate vaccine has become a direction for bacterial vaccine de-velopment ., but different conjugate technologies from different independent research groups also brought some confusion . After reviewing the research history of some representative team , conjugate methods , carrier protein , vaccine formulation and other hot topics were discussed .