CAJ | 학술논문

Sox2是Sox家族中的重要成员之一，在调控早期胚胎及正常组织的发育，维持干细胞的多功能性、祖细胞的自我更新能力和决定细胞命运等方面发挥重要作用。 Sox2基因的突变或缺失有可能导致发育异常或先天性疾病。既往研究表明，Sox2在多种恶性肿瘤组织中表达，并且与恶性肿瘤的发生、淋巴结的转移、病理分级及临床分期有关。所以，Sox2被认为是一种潜在的致癌因子，其过表达可能是导致不同种类恶性肿瘤发生和发展的作用机制之一。
Sox2시Sox가족중적중요성원지일，재조공조기배태급정상조직적발육，유지간세포적다공능성、조세포적자아경신능력화결정세포명운등방면발휘중요작용。 Sox2기인적돌변혹결실유가능도치발육이상혹선천성질병。기왕연구표명，Sox2재다충악성종류조직중표체，병차여악성종류적발생、림파결적전이、병리분급급림상분기유관。소이，Sox2피인위시일충잠재적치암인자，기과표체가능시도치불동충류악성종류발생화발전적작용궤제지일。
Sox2 is one of the important members of the Soxfamily ,It plays an import role in the regulation of early embryo and normal tissue development ,maintain the versatility of stem cells and progenitor cells self -re-newal ability and decide cell fate ,etc.Sox2 genetic mutation or missing may lead to dysplasia or congenital disea-ses.Previous studies showed that Sox 2 expressed in a variety of malignant tumors ,and associated with the inci-dence of malignant tumor ,lymph node metastasis and pathological grading and clinical staging .There fone Sox2 is considered as a potential carcinogenic factor ,its over expression may form one of development of mechanisms for the occurrence and different kinds of malignant tumor .