北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2013年
8期
6-7,8
,共3页
龚又明%方莉%林华%邓广海%冯倩茹
龔又明%方莉%林華%鄧廣海%馮倩茹
공우명%방리%림화%산엄해%풍천여
附子%炮制品%酯型生物碱%总生物碱%含量测定
附子%砲製品%酯型生物堿%總生物堿%含量測定
부자%포제품%지형생물감%총생물감%함량측정
Aconiti Lateralis Radix Praeparata%Processed products%Ester alkaloids%Total alkaloids%Determination of content
目的:比较附子不同部位及其炮制品生物碱含量变化。方法:采用HPLC法同时测定附子不同部位及其炮制品中6种单、双酯型生物碱的含量,采用滴定法测定其总生物碱含量,分析其不同部位及其炮制品生物碱含量的变化。结果:单酯型生物碱大小依次为:制附子皮>黑顺片>白附片>附子皮>生附子,双酯型生物碱大小为:附子皮>生附子>制附子皮>黑顺片>白附片,总生物碱大小为:附子皮>生附子>制附子皮>黑顺片>白附片。结论:附子皮中生物碱的含量高,毒性大,为了保证其临床有效性与安全性,黑顺片与白附片临床应用应有所区分。
目的:比較附子不同部位及其砲製品生物堿含量變化。方法:採用HPLC法同時測定附子不同部位及其砲製品中6種單、雙酯型生物堿的含量,採用滴定法測定其總生物堿含量,分析其不同部位及其砲製品生物堿含量的變化。結果:單酯型生物堿大小依次為:製附子皮>黑順片>白附片>附子皮>生附子,雙酯型生物堿大小為:附子皮>生附子>製附子皮>黑順片>白附片,總生物堿大小為:附子皮>生附子>製附子皮>黑順片>白附片。結論:附子皮中生物堿的含量高,毒性大,為瞭保證其臨床有效性與安全性,黑順片與白附片臨床應用應有所區分。
목적:비교부자불동부위급기포제품생물감함량변화。방법:채용HPLC법동시측정부자불동부위급기포제품중6충단、쌍지형생물감적함량,채용적정법측정기총생물감함량,분석기불동부위급기포제품생물감함량적변화。결과:단지형생물감대소의차위:제부자피>흑순편>백부편>부자피>생부자,쌍지형생물감대소위:부자피>생부자>제부자피>흑순편>백부편,총생물감대소위:부자피>생부자>제부자피>흑순편>백부편。결론:부자피중생물감적함량고,독성대,위료보증기림상유효성여안전성,흑순편여백부편림상응용응유소구분。
Objective: To compare the the content changes of different parts and its processed products of Aconiti Lateralis Radix Praeparata. Methods: Using the method of HPLC to determine the content of six kinds of diesterifiable, monoester alkaloids of different parts and its processed products of Aconiti Lateralis Radix Praeparata,the method of titration to determine the content of its total alkaloid,analysis of its different parts and its processed products alkaloid content changes . Results: Monoester alkaloids size order was: Processed products of cortex of Aconiti Lateralis Radix Praeparata > Hei shun pian > Bai fu pian > cortex of Aconiti Lateralis Radix Praeparata > Aconiti Lateralis Radix Praeparata,Diester the alkaloids size order was: cortex of Aconiti Lateralis Radix Praeparata > Aconiti Lateralis Radix Praeparata > Processed Products of cortex of Aconiti Lateralis Radix Praeparata> Hei shun pian > Bai fu pian,the total alkaloids size order was: cortex of Aconiti Lateralis Radix Praeparata > Aconiti Lateralis Radix Praeparata > Processed Products of cortex of Aconiti Lateralis Radix Praeparata> Hei shun pian > Bai fu pian. Conclusions: There was higher content of alkaloids and toxicity in cortex of Aconiti Lateralis Radix Praeparata,in order to ensure its clinical efficacy and safety of Hei shun pian with Bai fu pian,we should be separate in monkshood clinical applications.