4-甲基-8-甲酰基-7-羟基香豆素的合成
4-갑기-8-갑선기-7-간기향두소적합성
Synthesis of 8-formyl-7-hydroxyl-4-methylcoumarin
  • 万方数据
    广东化工 엄동화공
    GUANGDONG CHEMICAL INDUSTRY
    2012年 17期 166-167 ,共2页

    黄志平%郑超%周蕾%樊启平%向玉联%张鸣

    황지평%정초%주뢰%번계평%향옥련%장명

    香豆素%Pechmarm反应%Duff反应%合成 香豆素%Pechmarm反應%Duff反應%閤成
    향두소%Pechmarm반응%Duff반응%합성
    coumarin%pechmannreaction%duffreaction%synthesis
    香豆素衍生物是药物开发和荧光探针设计的重要中间体。文章以间苯52酚和乙酰乙酸乙酯为起始原料，经Pechmann反应和Duff反应两步合成了4-甲基-8-甲酰基-7-羟基香豆素，并优化了反应条件。
    향두소연생물시약물개발화형광탐침설계적중요중간체。문장이간분52분화을선을산을지위기시원료，경Pechmann반응화Duff반응량보합성료4-갑기-8-갑선기-7-간기향두소，병우화료반응조건。
    Coumarin derivatives are important compounds for drug development and fluorescent probe design. In the paper, 8-formyl-7-hydroxyl-4- methylcomnarin was prepared by Pechmann reaction and Duff reaction using resorcinol and ethyl acetoacetatc as raw materials. The reaction conditions were investigated.
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