CAJ | 학술논문

1例67岁男性患者因牙龈炎口服奥硝唑(1.0g,1次/d)、头孢拉啶(0.5g,3次/d)和对乙酰氨基酚(0.5g,2次/d).3d后疼痛减轻,但出现头晕、头痛及乏力症状.停用头孢拉啶和对乙酰氨基酚,继续服用奥硝唑.4d后患者突然出现精神异常,症状昼轻夜重,脑电图检查示α波频率变慢,出现散在不规则θ波,诊断为谵妄.停用奥硝唑,给予氟哌啶醇5 mg,1次/d肌内注射;维生素B60.2 g、三磷酸腺苷40 mg、辅酶A200 U以及维生素C2.0g加入10％葡萄糖氯化钠注射液1000 ml中静脉滴注,1次/d;奥氮平5～10 mg,2次/d口服.3d后患者神志恢复,停用氟哌啶醇;奥氮平减量至0.25 g,1次/d口服.治疗第6天患者头晕、头痛及乏力消失,体力恢复,脑电图检查正常.第7天停用抗精神病药.随访3个月余,患者精神状态正常.
1례67세남성환자인아간염구복오초서(1.0g,1차/d)、두포랍정(0.5g,3차/d)화대을선안기분(0.5g,2차/d).3d후동통감경,단출현두훈、두통급핍력증상.정용두포랍정화대을선안기분,계속복용오초서.4d후환자돌연출현정신이상,증상주경야중,뇌전도검사시α파빈솔변만,출현산재불규칙θ파,진단위섬망.정용오초서,급여불고정순5 mg,1차/d기내주사;유생소B60.2 g、삼린산선감40 mg、보매A200 U이급유생소C2.0g가입10％포도당록화납주사액1000 ml중정맥적주,1차/d;오담평5～10 mg,2차/d구복.3d후환자신지회복,정용불고정순;오담평감량지0.25 g,1차/d구복.치료제6천환자두훈、두통급핍력소실,체력회복,뇌전도검사정상.제7천정용항정신병약.수방3개월여,환자정신상태정상.
A 67-year-old male patient with gingivitis received ornidazole orally 1.0 g once daily,cefradine 0.5 g thrice daily,and paracetamol 0.5 g twice daily.Three days later,the pain was relieved,but the patient developed dizziness,headache,and fatigue.Cefradine and paracetamol were stopped and ornidazole was continued.Four days later,the patient developed sudden mental disorder,which was mild during the daytime and severe at night.EEG examination revealed that frequency of α waves became slow and irregular and scattered θ waves appeared.The patient was diagnosed with delirium.Ornidazole was stopped.IM haloperidol 5 mg once daily,Ⅳ infusion of vitamin B6 0.2 g,adenosine triphosphate 40 mg,coenzyme A 200 U,and vitamin C 2.0 g in 10％ glucose and sodium chloride injection 1000 ml,and oral olanzapine 5 to 10 mg twice daily were given.Three days later,the patient's consciousness recovered.Then,haloperidol was stopped and the dose of olanzapine was reduced to 0.25 g once daily.On day 6 of treatments,the patient's dizziness,headache,and fatigue disappeared,physical strength recovered,and EEG examination showed normal results.On day 7 of treatments,antipsychotics were discontinued.After more than 3 months of follow-up,the patient's mental state was normal.