CAJ | 학술논문

目的评价头颈部淋巴结超声造影( contrast-enhanced ultrasound,CEUS)时间-强度曲线( time-intensity curve,TIC)参数在良、恶性病变鉴别诊断中的价值。方法对85名头颈部淋巴结病变的患者(85枚淋巴结,良恶性各为36枚和49枚)进行CEUS。设置感兴趣区( region of interest,ROI)于整个淋巴结、皮质最明显增强区、皮质最弱或无增强区、髓质-门区域、周围软组织。对获得的TIC参数(基础强度、峰值强度、上升支斜率、始增时间、达峰时间、上升时间、峰值浓度减半时间、平均渡越时间)进行分析比较。通过对皮质最明显增强区的上升时间接收者操作特征曲线( receiver operating characteristic curve,ROC)分析,计算出诊断良恶性淋巴结的界值( cut off value)。结果恶性淋巴结在皮质最明显增强区的上升时间明显短于良性淋巴结( P=0.041)。结论 ROI设置于皮质最明显增强区域时TIC的上升时间对头颈部淋巴结良恶性病变的鉴别诊断具有重要意义。
목적평개두경부림파결초성조영( contrast-enhanced ultrasound,CEUS)시간-강도곡선( time-intensity curve,TIC)삼수재량、악성병변감별진단중적개치。방법대85명두경부림파결병변적환자(85매림파결,량악성각위36매화49매)진행CEUS。설치감흥취구( region of interest,ROI)우정개림파결、피질최명현증강구、피질최약혹무증강구、수질-문구역、주위연조직。대획득적TIC삼수(기출강도、봉치강도、상승지사솔、시증시간、체봉시간、상승시간、봉치농도감반시간、평균도월시간)진행분석비교。통과대피질최명현증강구적상승시간접수자조작특정곡선( receiver operating characteristic curve,ROC)분석,계산출진단량악성림파결적계치( cut off value)。결과악성림파결재피질최명현증강구적상승시간명현단우량성림파결( P=0.041)。결론 ROI설치우피질최명현증강구역시TIC적상승시간대두경부림파결량악성병변적감별진단구유중요의의。
Objective To evaluate the value of the time-intensity curve ( TIC ) of contrast-enhanced ultrasound ( CEUS ) in differentiation of malignant from benign lymph nodes of the head and neck. Methods Eighty-five patients with enlarged cervical lymph nodes(85 lesions) were examined with CEUS. Of 85 nodes, 36 benign and 49 malignant lesions were proved histopathologically. Region of interest( ROI) was placed in whole lymph nodes, the most evident enhanced area of the cortex, the weakest enhanced area of the cortex, medulla-hilar area, and soft tissue next to the node, respectively. Eight TIC parameters( basic intensity, peak intensity, wash in slope, arrival time, time to peak, rise time, time from peak to one half, and mean transit time) were compared between malignant and benign nodes. Finally the malignant lymph nodes were evaluated by the ROC curve drawn with the rise time, and meanwhile the cut off value was obtained. Results The rise time of ROI that was placed on the most evidently enhanced area of the cortex of cervical lymph nodes was significantly shorter in malignant than benign lesions(P=0. 041). Conclusion The rise time value obtained from most evidently enhanced areas of the lymph node cortex could help differentiate malignant from benign nodes of the head and neck.