国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
15期
2327-2330
,共4页
加巴喷丁%盐酸羟考酮控释片%癌痛
加巴噴丁%鹽痠羥攷酮控釋片%癌痛
가파분정%염산간고동공석편%암통
Gabapentin%Oxycodone hydrochloride%Cancer pain
目的 观察加巴喷丁联合盐酸羟考酮控释片治疗中重癌痛的效果及对生活质量的影响.方法 78例中重度癌痛患者按数字随机法分为盐酸羟考酮控释片单药组及辅用加巴喷丁联合组,两组分别给予盐酸羟考酮控释片单药及辅用加巴喷丁两药,2周后评估镇痛效果、生活质量及不良反应.结果 镇痛有效缓解率单药组(78.9％)与联合组(89.7％)比较差异有统计学意义(Z=3.717,P=0.000);治疗后两组生活质量评分结果比较,联合组优于单药组(t=2.870,P=0.005);单药组及联合组治疗前后生活质量评分比较差异有统计学意义(t=5.389、5.999,P=0.000);两组不良反应类似.结论 加巴喷丁联合盐酸羟考酮控释片可有效控制癌痛,改善患者生活质量.
目的 觀察加巴噴丁聯閤鹽痠羥攷酮控釋片治療中重癌痛的效果及對生活質量的影響.方法 78例中重度癌痛患者按數字隨機法分為鹽痠羥攷酮控釋片單藥組及輔用加巴噴丁聯閤組,兩組分彆給予鹽痠羥攷酮控釋片單藥及輔用加巴噴丁兩藥,2週後評估鎮痛效果、生活質量及不良反應.結果 鎮痛有效緩解率單藥組(78.9％)與聯閤組(89.7％)比較差異有統計學意義(Z=3.717,P=0.000);治療後兩組生活質量評分結果比較,聯閤組優于單藥組(t=2.870,P=0.005);單藥組及聯閤組治療前後生活質量評分比較差異有統計學意義(t=5.389、5.999,P=0.000);兩組不良反應類似.結論 加巴噴丁聯閤鹽痠羥攷酮控釋片可有效控製癌痛,改善患者生活質量.
목적 관찰가파분정연합염산간고동공석편치료중중암통적효과급대생활질량적영향.방법 78례중중도암통환자안수자수궤법분위염산간고동공석편단약조급보용가파분정연합조,량조분별급여염산간고동공석편단약급보용가파분정량약,2주후평고진통효과、생활질량급불량반응.결과 진통유효완해솔단약조(78.9％)여연합조(89.7％)비교차이유통계학의의(Z=3.717,P=0.000);치료후량조생활질량평분결과비교,연합조우우단약조(t=2.870,P=0.005);단약조급연합조치료전후생활질량평분비교차이유통계학의의(t=5.389、5.999,P=0.000);량조불량반응유사.결론 가파분정연합염산간고동공석편가유효공제암통,개선환자생활질량.
Objective To investigate curative effect and safety of gabapentin combined with oxycodone hydrochloride controlled-release tablets in treatment of moderate and severe cancer pain.Methods 78 patients with moderate or severe cancer pain were divided into oxycodone hydrochloride controlled-release tablets single group and assisted with gabapentin combined group randomly.The patients were treated with single oxycodone hydrochloride controlled-release tablets and with combination of gahapentin caps and oxycodone hydrochloride controlled-release tablets respectively.After treatment of 2 weeks the analgesic effect,quality of life and adverse reactions were assessed.Results Single drug group analgesic effective relief rate was 78.9％ and that of the combined group was 89.7％.There was statistical significant difference between two groups about the analgesic effect (Z=3.717,P=0.000).Quality of life score results were compared between the two groups after treatment,combined group was better than the single drug group (t=2.870,P=0.005).There were significant differences about quality of life score before and after the single drug group and combined treatment group (t=5.389,t=5.999,P=0.000).The adverse reactions in two groups were the same.Conclusion Gabapentin combined with oxycodone hydrochloride controlled-release tablets can effectively control cancer pain and improve quality of life in patients with cancer pain.
