CAJ | 학술논문

刺猬( hedgehog,Hh)信号通路是一条与成骨相关的信号通路。在胚胎发育期间,它调控祖细胞的生长和分化及各组织的形成。当肝脏受到损伤后,这条信号通路被激活。活化的Hh信号通路参与肝损伤修复反应的多个方面,包括肝祖细胞的增殖,肌成纤维细胞的转化与生成,肝脏多种细胞的凋亡,与肝损伤引起的炎症反应以及血管重塑过程等。该文将对近年来Hh信号通路参与肝损伤修复机制的研究及可能的药物作用靶点作一综述,旨在为抗肝纤维化的研究提供新的视角和治疗靶标。
자위( hedgehog,Hh)신호통로시일조여성골상관적신호통로。재배태발육기간,타조공조세포적생장화분화급각조직적형성。당간장수도손상후,저조신호통로피격활。활화적Hh신호통로삼여간손상수복반응적다개방면,포괄간조세포적증식,기성섬유세포적전화여생성,간장다충세포적조망,여간손상인기적염증반응이급혈관중소과정등。해문장대근년래Hh신호통로삼여간손상수복궤제적연구급가능적약물작용파점작일종술,지재위항간섬유화적연구제공신적시각화치료파표。
Hedgehog pathway is an osteogenesis-related signaling pathway . During embryonic development , it regulates the growth and proliferation of progenitor cells and tissue formation. This pathway can be activated during liver injury. Activated Hedge-hog signaling pathway is involved in many aspects of liver wound-healing responses, including hepatic progenitor cell pro-liferation, myofibroblast transdifferentiation, apoptosis of various types of liver cells, inflammatory reactions, and vascular remod-eling. This article reviews the research progress in the role of Hedgehog signaling pathway in liver injury and the underlying mechanisms. The potential drug targets are also discussed. This review is to provide novel insights into antifibrotic research and therapeutic targets.