CAJ | 학술논문

翻译是细胞中基因表达调控的一个基本步骤,该环节的异常可能会导致肿瘤的发生。在真核生物的细胞内,mR-NA的翻译受到许多真核起始因子( eukaryotic initiation fac-tor,eIF)的调控。起始因子eIF3在转录调控,细胞生长和肿瘤的发生中发挥了重要的作用,它的最大的亚基eIF3a可能作为一个mRNA调节器发挥作用。已发现eIF3a与肿瘤的发生相关,并广泛表达于多种肿瘤组织细胞内,调节肿瘤细胞的周期,但对于进展中的肿瘤细胞,eIF3a的表达可能与肿瘤细胞的进展过程负相关；对于化疗药物干预的肿瘤细胞, eIF3a的高表达使肿瘤细胞不易发生耐药,患者的预后更好。关于eIF3a与肿瘤的关系的研究目前还不是很清楚,eIF3a可能参与了肿瘤的病理生理进程,但其发挥的调节作用可能是波动性的。
번역시세포중기인표체조공적일개기본보취,해배절적이상가능회도치종류적발생。재진핵생물적세포내,mR-NA적번역수도허다진핵기시인자( eukaryotic initiation fac-tor,eIF)적조공。기시인자eIF3재전록조공,세포생장화종류적발생중발휘료중요적작용,타적최대적아기eIF3a가능작위일개mRNA조절기발휘작용。이발현eIF3a여종류적발생상관,병엄범표체우다충종류조직세포내,조절종류세포적주기,단대우진전중적종류세포,eIF3a적표체가능여종류세포적진전과정부상관；대우화료약물간예적종류세포, eIF3a적고표체사종류세포불역발생내약,환자적예후경호。관우eIF3a여종류적관계적연구목전환불시흔청초,eIF3a가능삼여료종류적병리생리진정,단기발휘적조절작용가능시파동성적。
Translation is a fundamental step in regulation of gene expression and abnormalities in this process may lead to cancer. In eukaryotic cells, translation of mRNA is mainly regulated by many eukaryotic initiation factors ( eIFs) . EIF3 plays an impor-tant role in translational regulation, cell growth and oncogenesis. The largest subunit of eIF3, eIF3a may play a role as a regulator of mRNAs. The relationship between eIF3a and oncogenesis has been found. Moreover, the eIF3a mRNA is ubiquitously ex-pressed in different cancer cells and can modulate the cell cycle. However, some studies indicate that eIF3a could provide protec-tion against evolution into higher malignancy and reduce the re-sistance to chemotherapy . The patients of high eIF3a expression could get a better prognosis . In fact, the role of eIF3a is still un-clear in cancer cells. EIF3a may be involved in the process of tumor pathophysiology, but its regulatory role is undulatory.