CAJ | 학술논문

磷酸二酯酶-4(phosphodiesterase-4, PDE4)对细胞内环腺苷酸( cyclic adenosine monophosphate, cAMP)浓度及其下行信号传导具有重要调控作用,是近年来备受关注的新型药物治疗靶点。 PDE4在中枢神经系统具有广泛表达,其4个亚型的分布和功能各具特征。国内外近期研究发现, PDE4在抑郁、认知记忆障碍、药物依赖、神经损伤等疾病进程中发挥重要作用。特异性PDE4抑制剂的研发,可为上述疾病的治疗提供新的路径。该文就近年来PDE4中枢功能的研究进展作一简要综述,并探讨其作为神经精神疾病新型治疗靶点的应用前景。
린산이지매-4(phosphodiesterase-4, PDE4)대세포내배선감산( cyclic adenosine monophosphate, cAMP)농도급기하행신호전도구유중요조공작용,시근년래비수관주적신형약물치료파점。 PDE4재중추신경계통구유엄범표체,기4개아형적분포화공능각구특정。국내외근기연구발현, PDE4재억욱、인지기억장애、약물의뢰、신경손상등질병진정중발휘중요작용。특이성PDE4억제제적연발,가위상술질병적치료제공신적로경。해문취근년래PDE4중추공능적연구진전작일간요종술,병탐토기작위신경정신질병신형치료파점적응용전경。
Phosphodiesterase-4 ( PDE4 ) has been one of the most popular drug targets during recent years due to its critical role in the control of intracellular cyclic adenosine monophos-phate ( cAMP ) concentration and downstream signal transduc-tion. PDE4 is widely distributed in the central nervous system ( CNS) with different expression levels of its four subtypes. Re-cent data indicate that altered PDE4 expression and/or activity is relevant to multiple CNS disorders, such as depression, memory deficiency, drug dependence, and neural lesion. Selective PDE4 inhibitors exhibit therapeutic effects on these disorders and might be a promising pharmacotherapy. The paper highlights recent re-search progress in the roles of PDE4 in CNS function, and dis-cusses the prospects of PDE4 as a novel therapeutic target for CNS disorders.