CAJ | 학술논문

目的：综述脑靶向纳米载体系统的研究进展。方法：收集相关最新发表的文献，对纳米载体给药系统透过血脑屏障对中构神经系统疾病的治疗进行分析总结。结果与结论：血脑屏障成为治疗神经系统疾病过程的一道难题，血脑屏障既可以保护大脑不受外界有害物质的侵害，维持脑部内环境的稳定，同时也限制了药物进入脑部发挥其治疗作用。随着纳米技术的发展，纳米药物载体系统（如脂质体，聚合物纳米粒，胶束，纳米凝胶，微乳和固体脂质纳米粒）的应用使药物的跨血脑屏障转运和脑内传递成为可能。这将该变脑部疾病的治疗策略。
목적：종술뇌파향납미재체계통적연구진전。방법：수집상관최신발표적문헌，대납미재체급약계통투과혈뇌병장대중구신경계통질병적치료진행분석총결。결과여결론：혈뇌병장성위치료신경계통질병과정적일도난제，혈뇌병장기가이보호대뇌불수외계유해물질적침해，유지뇌부내배경적은정，동시야한제료약물진입뇌부발휘기치료작용。수착납미기술적발전，납미약물재체계통（여지질체，취합물납미립，효속，납미응효，미유화고체지질납미립）적응용사약물적과혈뇌병장전운화뇌내전체성위가능。저장해변뇌부질병적치료책략。
Objective: To review the latest research progress on brain-targeted nano-carrier systems. Methods:Recent published literatures on brain-targeted nano-carrier systems for the treatment of central nervous system diseases were col ected, analyzed and summarized. Results and conclusion:The blood-brain barrier (BBB) is considered to be the major obstacle in treating central nervous system diseases. BBB can make brain far away from harmful substances and maintain the steady state of microenvironment of brain. Meanwhile BBB also gives rise to the poor penetration of drugs into brain. With the development of nanotechnology, the nanocarriers such as liposomes, nanoparticles, micel es, nanogel, microemulsion and solid lipid nanoparticles for delivering drugs make it possible to transport drugs across the BBB. Therefore, possible strategies for brain-targeting could be available.