CAJ | 학술논문

目的：探讨急性脑梗死患者的炎症因子基因表达水平与颈动脉斑块的关系。方法对128例脑梗死患者、65例对照组外周血进行白介素6(IL 6)、白介素10(IL 10)、肿瘤坏死因子α(TNF α)mRNA表达的测定以及颈动脉超声检查颈动脉斑块情况。结果脑梗死组 IL 6、IL 10mRNA表达水平与对照组比较差异有统计学意义(P<0.05),颈动脉不稳定斑块、高度狭窄的比例较对照组明显升高(P<0.05)。稳定斑块组 IL 6 mRNA、TNF αmRNA表达水平明显高于对照组,IL 10 mRNA表达水平明显低于对照组,差异有统计学意义(P<0.05)。结论急性脑梗死患者血清炎症因子基因表达水平与颈动脉斑块形成及其稳定性密切相关。
목적：탐토급성뇌경사환자적염증인자기인표체수평여경동맥반괴적관계。방법대128례뇌경사환자、65례대조조외주혈진행백개소6(IL 6)、백개소10(IL 10)、종류배사인자α(TNF α)mRNA표체적측정이급경동맥초성검사경동맥반괴정황。결과뇌경사조 IL 6、IL 10mRNA표체수평여대조조비교차이유통계학의의(P<0.05),경동맥불은정반괴、고도협착적비례교대조조명현승고(P<0.05)。은정반괴조 IL 6 mRNA、TNF αmRNA표체수평명현고우대조조,IL 10 mRNA표체수평명현저우대조조,차이유통계학의의(P<0.05)。결론급성뇌경사환자혈청염증인자기인표체수평여경동맥반괴형성급기은정성밀절상관。
Objective To investigate the relationship between inflammatory factors gene expression and carotid plaque in patients with acute cerebral infarction (ACI).Methods The levels of interleukin (IL) 6,IL 10,tumor necrosis factor α(TNF α)gene expression were measured in128 patients with ACI and 65 controls.The carotid plaque was assessed by color Doppler ultrasound.Re-sults There was significant difference in the levels of IL 6 and IL 10 mRNA expression between patients with cerebral infarction and controls.The ratio of carotid instability plaque in patients with ACI was much higher than that in controls.The inflammatory fac-tors mRNA expression was more unusual in patients with carotid instability plaque.Conclusion The level of serum inflammatory factors gene expression in patients with ACI was closely related with plaque formation and plaque stability.