CAJ | 학술논문

目的：观察疏肝益心汤治疗冠心病不稳定型心绞痛(气滞痰瘀证)的临床疗效。方法将60例不稳定型心绞痛患者随机分成两组,对照组予单硝酸异山梨酯胶囊、阿司匹林肠溶片、氯吡格雷、酒石酸美托洛尔片治疗。治疗组在对照组治疗基础上加服疏肝益心汤,两次口服150 mL,2次/日,分别于早餐及晚餐半小时后服用,4周为1个疗程。观察比较两组患者中医证候、心绞痛及心电图疗效,临时服用硝酸甘油停减量、血脂、C 反应蛋白水平变化及不良反应。结果治疗后两组中医证候积分、心绞痛、心电图、临时服用硝酸甘油停减量、血脂、C反应蛋白水平等情况较治疗前均有改善(P<0.05)；治疗组治疗后中医证候积分、心绞痛显效率、临时服用硝酸甘油停减量及C 反应蛋白水平改善均优于对照组(P<0.05)。结论疏肝益心汤是治疗冠心病不稳定型心绞痛(气滞痰瘀证)的安全有效方剂之一,对治疗不稳定型心绞痛有一定的临床意义。
목적：관찰소간익심탕치료관심병불은정형심교통(기체담어증)적림상료효。방법장60례불은정형심교통환자수궤분성량조,대조조여단초산이산리지효낭、아사필림장용편、록필격뢰、주석산미탁락이편치료。치료조재대조조치료기출상가복소간익심탕,량차구복150 mL,2차/일,분별우조찬급만찬반소시후복용,4주위1개료정。관찰비교량조환자중의증후、심교통급심전도료효,림시복용초산감유정감량、혈지、C 반응단백수평변화급불량반응。결과치료후량조중의증후적분、심교통、심전도、림시복용초산감유정감량、혈지、C반응단백수평등정황교치료전균유개선(P<0.05)；치료조치료후중의증후적분、심교통현효솔、림시복용초산감유정감량급C 반응단백수평개선균우우대조조(P<0.05)。결론소간익심탕시치료관심병불은정형심교통(기체담어증)적안전유효방제지일,대치료불은정형심교통유일정적림상의의。
Objective To observe the clinical efficacy of Shugan Yixin decoction (SYD)for treatment of unstable pectoris (UAP) with syndrome of qi stagnation,phlegm and blood stasis.Methods Sixty patients with UAP were randomly divided into two groups:Control group treated with western medicine,and treatment group treated with western medicine and SYD for 30 days.The curative effect was observed.Evaluations were provided separately on the curative effects of traditional Chinese medicine (TCM)symptoms, angina pectoris,ECG curative effect,nitroglycerin consumption,lipid levels,CRP level,and adverse reaction.Results After treat-ment,angina,ECG,nitroglycerin consumption,blood fat,and CRP level were improved (P<0.05).After treatment,angina pectoris efficiency,nitroglycerin consumption,and CRP level in treatment group were better than that in control group (P<0.05).Conclusion SYD was safe and effective for treatment of UAP with syndrome of qi stagnation,phlegm and blood stasis.