CAJ | 학술논문

研究了黄腐酸（FA）作为一种的新的络合剂,与羟丙基-β-环糊精络合物（Hp-β-CD）相比,对阿司匹林（ASA）分解的影响。ASA与FA以1：0.5、1：1、1：2（物质的量比）络合,并用冷冻干燥、溶剂蒸发和喷雾干燥三种方法进行干燥。ASA-羟丙基-β-环糊精（1：1）络合物通过喷雾干燥制备,并与最佳FA络合物进行比较。将所有的络合物和ASA放入贴好标签的铝塑小包中密封,在温度为40±2℃、相对湿度为75%±5%的稳定暗箱中存放120d。分别在0、30d、60d、90d和120d分析各样品的水杨酸含量。以物质的量比为1：1进行络合的ASA-FA喷雾干燥络合物中水杨酸含量为4.31%,该络合物在所有不同制备方法的络合物中具有最佳稳定性。然而,1：1的ASA-羟丙基-β-环糊精喷雾干燥络合物中测得水杨酸含量只有2.35%。与FA相比,ASA与羟丙基-β-环糊精络合,其稳定性更强。为提高阿司匹林的稳定性,对一种新型FA络合剂进行了研究。与1：1ASA-FA喷雾干燥络合物相比,ASA与羟丙基-β-环糊精1：1络合时,ASA的稳定性有显著改善。
연구료황부산（FA）작위일충적신적락합제,여간병기-β-배호정락합물（Hp-β-CD）상비,대아사필림（ASA）분해적영향。ASA여FA이1：0.5、1：1、1：2（물질적량비）락합,병용냉동간조、용제증발화분무간조삼충방법진행간조。ASA-간병기-β-배호정（1：1）락합물통과분무간조제비,병여최가FA락합물진행비교。장소유적락합물화ASA방입첩호표첨적려소소포중밀봉,재온도위40±2℃、상대습도위75%±5%적은정암상중존방120d。분별재0、30d、60d、90d화120d분석각양품적수양산함량。이물질적량비위1：1진행락합적ASA-FA분무간조락합물중수양산함량위4.31%,해락합물재소유불동제비방법적락합물중구유최가은정성。연이,1：1적ASA-간병기-β-배호정분무간조락합물중측득수양산함량지유2.35%。여FA상비,ASA여간병기-β-배호정락합,기은정성경강。위제고아사필림적은정성,대일충신형FA락합제진행료연구。여1：1ASA-FA분무간조락합물상비,ASA여간병기-β-배호정1：1락합시,ASA적은정성유현저개선。
The degradation of aspirin(ASA) was investigated to reveal information about the influence of complexation with fulvic acid(FA),as a new complexing agent and compared with hydroxy propyl-β-cyclodextrin complex.ASA was complexed with FA in the molar ratio 1:0.5,1:1,and 1:2 by different methods through lyophilization,solvent evaporation,and spray drying.Spray-dried(1:1) ASA-hydroxy propyl-β-cyclodextrin complex was prepared and compared with optimized complex of FA.All the complexes and ASA alone were packaged in well-labeled sealed polythene-lined aluminum pouches and stored in stability chamber at 40 ± 2 °C and 75 ± 5 % relative humidity for 120 days.Samples were analyzed for salicylic acid content at 0,30,60,90,and 120 days.Overall 4.31% salicylic acid was formed in 1:1 ASA-FA spray-dried complex,which was optimized stable complex among other complexes of FA prepared by different methods in different molar ratios.However,2.35% salicylic acid was measured with 1:1 spray-dried ASA-hydroxy propyl-β-cyclodextrin complex.Stability of ASA increased more when complexed with hydroxy propyl-β-cyclodextrin as compared to FA.A novel complexing agent in the form of FA was investigated to increase the stability of ASA.Amarked improvement in stability of ASA was observed when complexed with hydroxy propyl-β-cyclodextrin(1:1) by spray drying as compared to 1:1 spray-dried ASA-FA complex.