西华师范大学学报：自然科学版
西華師範大學學報：自然科學版
서화사범대학학보：자연과학판
Journal of China West Normal University:Natural Science Edition
2012年
4期
343-349,355
,共8页
刘亚男%康泰然%倪承燕%何龙%刘全忠
劉亞男%康泰然%倪承燕%何龍%劉全忠
류아남%강태연%예승연%하룡%류전충
盐酸羟胺%不饱和酮酸酯%异恶唑烷%共轭加成
鹽痠羥胺%不飽和酮痠酯%異噁唑烷%共軛加成
염산간알%불포화동산지%이악서완%공액가성
hydroxylamine hydrochloride%unsaturated keto ester%isoxzolidine%conjugate addition
盐酸羟胺与不饱和酮酸酯的共轭加成反应已有报道．其共轭加成形成的半缩醛型化合物可用于合成高产率的异恶唑烷．作者探究了不饱和酮酸酯与盐酸羟胺在三乙胺的作用下形成恶唑烷衍生物的反应，常温条件下产率可达到98％．
鹽痠羥胺與不飽和酮痠酯的共軛加成反應已有報道．其共軛加成形成的半縮醛型化閤物可用于閤成高產率的異噁唑烷．作者探究瞭不飽和酮痠酯與鹽痠羥胺在三乙胺的作用下形成噁唑烷衍生物的反應，常溫條件下產率可達到98％．
염산간알여불포화동산지적공액가성반응이유보도．기공액가성형성적반축철형화합물가용우합성고산솔적이악서완．작자탐구료불포화동산지여염산간알재삼을알적작용하형성악서완연생물적반응，상온조건하산솔가체도98％．
Conjugate addition of hydroxylamine hydrochloride to β, γ-unsaturated keto ester was reported. The conjugate adducts underwent a subsequent hemi-acetalisation forming the corresponding isoxazolidine in high yields. This article explored the reaction of β, γ-unsaturated keto seter with hydroxylamine hydrochloride catalyzed by triethylamine forming oxazolidine derivatives up to 98% yield at room temperature.
