江汉大学学报：自然科学版
江漢大學學報：自然科學版
강한대학학보：자연과학판
Journal of Jianghan University:Natural Sciences
2012年
5期
37-40
,共4页
香豆素-3-羧酸乙酯%水杨醛%丙二酸二乙酯%壳聚糖%合成%产率
香豆素-3-羧痠乙酯%水楊醛%丙二痠二乙酯%殼聚糖%閤成%產率
향두소-3-최산을지%수양철%병이산이을지%각취당%합성%산솔
Coumarin-3- ethyl--carboxylate%salicylaldehyde%diethylmalonate%chitosan%synthesis%yield
以壳聚糖为催化剂,以无水乙醇为溶剂,通过水杨醛与丙二酸二乙酯的Knoevenagel缩合反应合成香豆素-3-羧酸乙酯。对影响香豆素-3-羧酸乙酯产率的因素如反应物物质的量比、反应时间、催化剂用量、溶剂用量、反应温度等进行了研究。结果表明：丙二酸二乙酯0.06 mol、水杨醛0.05 mol、反应时间120 min、壳聚糖3.0 g、无水乙醇10.0 mL、反应温度70℃时,香豆素-3-羧酸乙酯的产率可达87%。催化剂催化效率高,对环境友好,可重复使用。
以殼聚糖為催化劑,以無水乙醇為溶劑,通過水楊醛與丙二痠二乙酯的Knoevenagel縮閤反應閤成香豆素-3-羧痠乙酯。對影響香豆素-3-羧痠乙酯產率的因素如反應物物質的量比、反應時間、催化劑用量、溶劑用量、反應溫度等進行瞭研究。結果錶明：丙二痠二乙酯0.06 mol、水楊醛0.05 mol、反應時間120 min、殼聚糖3.0 g、無水乙醇10.0 mL、反應溫度70℃時,香豆素-3-羧痠乙酯的產率可達87%。催化劑催化效率高,對環境友好,可重複使用。
이각취당위최화제,이무수을순위용제,통과수양철여병이산이을지적Knoevenagel축합반응합성향두소-3-최산을지。대영향향두소-3-최산을지산솔적인소여반응물물질적량비、반응시간、최화제용량、용제용량、반응온도등진행료연구。결과표명：병이산이을지0.06 mol、수양철0.05 mol、반응시간120 min、각취당3.0 g、무수을순10.0 mL、반응온도70℃시,향두소-3-최산을지적산솔가체87%。최화제최화효솔고,대배경우호,가중복사용。
Coumarin-3- ethyl--carboxylate was synthesized with salicylaldehyde and di- ethylmalonate by using absolute alcohol as solvent and chitosan as catalyst. Some factors that in- flunced the yield of coumarin-3- ethyl--carboxylate were studied. The results showed that the yield of coumarin-3- ethyl--carboxylate was up to 87% when diethylmalonate was 0. 06 mol, sal- icylaldehyde was 0.05 mol, chitosan was 3.0 g, the reaction time was 120 min, and absolute alcohol was 10 mL, the temperature was 70℃.
